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Efficient mapping of neuromodulation therapy parameters to complex biomarker spaces

Award Number: OT2OD030536
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: OTHER
PERIOD OF PERFORMANCE START DATE: 01/13/2021
PERIOD OF PERFORMANCE END DATE: 12/31/2022

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Efficient mapping of neuromodulation therapy parameters to complex biomarker spaces - Introduction: The neuromodulation field has seen many early successes in converting therapies into clinical application, but challenges remain in reducing off-target effects for new indications as well as targeting therapies to ensure clinical and commercial viability. Challenges have arisen validating preclinical successes in clinical settings due to the differences between preclinical and clinical subjects leading to different stimulation parameters required. These challenges have impeded the expansion of neuromodulation to new indications [Herring 2019]. Herein we aim to show how the information in the neural signals can be leveraged to quantify and avoid off-target effects [Ardell 2017] providing better specificity for future therapies. Outline of the project: We propose utilising existing SPARC data to build an efficient method of searching the stimulation parameter space using Bayesian Optimisation with Gaussian Processes as a data-efficient way of modelling the stimulation response function. Furthermore, we will build a machine learning model for mapping neural signals into a compressed representation (termed Neural Biomarkers) in order to interpret the body’s neural signals as effective measures of organ function. Finally, we validate both approaches in acute and chronic large animal models where stimulation parameters are searched extensively through the input space and further optimised against neural biomarkers derived from the neural signals.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2021	BIOS HEALTH LTD	8 BATEMAN MEWS	CAMBRIDGE	CAMBRIDGESHIRE			GBR	Trans-NIH Research Support	000	1	10/26/2023	NEW	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $525,696 )
2022	2022	BIOS HEALTH LTD	8 BATEMAN MEWS	CAMBRIDGE	CAMBRIDGESHIRE			GBR	Trans-NIH Research Support	001	1	1/1/2022	SUPPLEMENT FOR EXPANSION	$525,696
2022	2021	BIOS HEALTH LTD	8 BATEMAN MEWS	CAMBRIDGE	CAMBRIDGESHIRE			GBR	Trans-NIH Research Support	000	1	12/31/2021	NEW	$0
														Subtotal = $525,696

Issue Date FY: 2021 ( Subtotal = $859,337 )
2021	2021	BIOS HEALTH LTD	8 BATEMAN MEWS	CAMBRIDGE	CAMBRIDGESHIRE			GBR	Trans-NIH Research Support	000	1	1/13/2021	NEW	$859,337
														Subtotal = $859,337

Grand Total All Awards = $1,385,033

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Efficient mapping of neuromodulation therapy parameters to complex biomarker spaces

Award Number: OT2OD030536

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: OTHER

PERIOD OF PERFORMANCE START DATE: 01/13/2021

PERIOD OF PERFORMANCE END DATE: 12/31/2022

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