The potential impact of the work to be done if it were successfully implemented.
This proposal looks to establish three-way collaboration between SPARC, HuBMAP and Kids First
(SHKF) as a means to develop coherent anatomical knowledge/data management strategies
informed by clinical use-cases. SPARC seeks to apply, in the SHKF space, SPARC-related
infrastructure (e.g. SciCrunch platform , ApiNATOMY connectivity  and flatmaps, 3D dynamic
organ scaffolds ), procedures (e.g. curational pipeline) and expertise (e.g. clinical, knowledge- and
bio-engineering, neuroscientific) to foster SHKF molecular/tissue/phenotype interoperability in support
of discovery, modeling and hypothesis testing, initially in the areas of the neurology of the heart and
colon. In the long-term (beyond the immediate scope of this project), this effort is expected to also set
the stage, and eventually facilitate, modelling and simulation (M&S) efforts in the areas of physiology-based
pharmacokinetics (PBPK) and paediatric allometry (PA).