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Cancer Grand Challenges: Operations Management Application

Award Number: OT2CA262137
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: OTHER
PERIOD OF PERFORMANCE START DATE: 05/10/2021
PERIOD OF PERFORMANCE END DATE: 04/30/2026

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Cancer Grand Challenges: Operations Management Application - Cancer Research UK (CRUK) established its ‘Grand Challenge’ initiative in 2015 to support international, interdisciplinary teams of elite scientists and clinicians to address some of the biggest problems in cancer research. Following positive and productive discussions between CRUK and NCI in 2019, it was agreed that a partnership would be formed to evolve CRUK Grand Challenge into Cancer Grand Challenges (CGC). The two organisations signed a Memorandum of Understanding (MoU) in February 2020 committing to partner in funding four new teams biennially over three cycles. The partners agreed a number of guiding principles, namely that CGC will: Tackle important challenges in cancer that require a multi-disciplinary approach to solve, and span discovery, clinical and population sciences; Be developed and shaped in consultation with the global cancer research community; Be international, and enable the best scientists to collaborate irrespective of geographical boundaries; Provide funding at scale in order to enable imaginative thinking; Embrace partnerships with other funding agencies, commercial organisations and private philanthropists. The MoU also provided that CRUK would lead on the delivery of the operations for CGC, moreover that NCI would support through an other transactions agreement 50% of the properly vouchered costs per year (including the cost of time incurred by CRUK employees) incurred by CRUK in its role as operational manager, subject to available funds. This other transactions application/award details CRUK’s responsibilities, specifically coordinating: The challenge-setting process; The two-stage application process for each round of CGC; Meetings of the CGC Joint Steering Committee and Scientific Committee; The release of funding by CRUK and NCI to each participating institution; Annual and end-of-grant scientific and financial reporting from funded teams; The delivery of an annual Scientific Summit and trainee meeting; CGC advocacy activity; Efforts to market the initiative and communicate its impact. In delivering all of the above, CRUK will work in close collaboration and consultation with NCI.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,640,929 )
2025	2025	CANCER RESEARCH UK	2 REDMAN PLACE	LONDON				GBR	Cancer Cause and Prevention Research	001	1	8/1/2025	SUPPLEMENT FOR EXPANSION	$1,640,929
2025	2021	CANCER RESEARCH UK	2 REDMAN PLACE	LONDON				GBR	Cancer Cause and Prevention Research	000	1	7/31/2025	NEW	$0
														Subtotal = $1,640,929

Issue Date FY: 2024 ( Subtotal = $819,783 )
2024	2024	CANCER RESEARCH UK	2 REDMAN PLACE	LONDON				GBR	Cancer Cause and Prevention Research	001	1	9/9/2024	SUPPLEMENT FOR EXPANSION	$819,783
2024	2021	CANCER RESEARCH UK	2 REDMAN PLACE	LONDON				GBR	Cancer Cause and Prevention Research	000	1	9/9/2024	NEW	$0
														Subtotal = $819,783

Issue Date FY: 2023 ( Subtotal = $1,113,831 )
2023	2023	CANCER RESEARCH UK	2 REDMAN PLACE	LONDON				GBR	Cancer Cause and Prevention Research	000	1	8/21/2023	SUPPLEMENT FOR EXPANSION	$1,113,831
2023	2021	CANCER RESEARCH UK	2 REDMAN PLACE	LONDON				GBR	Cancer Cause and Prevention Research	001	1	8/23/2023	NEW	$0
														Subtotal = $1,113,831

Issue Date FY: 2022 ( Subtotal = $832,330 )
2022	2022	CANCER RESEARCH UK	2 REDMAN PLACE	LONDON				GBR	Cancer Cause and Prevention Research	003	1	9/19/2022	SUPPLEMENT FOR EXPANSION	$832,330
2022	2021	CANCER RESEARCH UK	2 REDMAN PLACE	LONDON				GBR	Cancer Cause and Prevention Research	001	1	10/26/2021	NEW	$913,614
2022	2021	CANCER RESEARCH UK	2 REDMAN PLACE	LONDON				GBR	Cancer Cause and Prevention Research	000	1	10/22/2021	NEW	-$913,614
2022	2021	CANCER RESEARCH UK	2 REDMAN PLACE	LONDON				GBR	Cancer Cause and Prevention Research	002	1	9/19/2022	NEW	$0
														Subtotal = $832,330

Issue Date FY: 2021 ( Subtotal = $913,614 )
2021	2021	CANCER RESEARCH UK	2 REDMAN PLACE	LONDON				GBR	Cancer Cause and Prevention Research	000	1	5/10/2021	NEW	$913,614
														Subtotal = $913,614

Grand Total All Awards = $5,320,487

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Cancer Grand Challenges: Operations Management Application

Award Number: OT2CA262137

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: OTHER

PERIOD OF PERFORMANCE START DATE: 05/10/2021

PERIOD OF PERFORMANCE END DATE: 04/30/2026

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