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Enhancing Disease Detection in Newborns: Building Capacity in Public Health Laboratories

Award Number: NU88EH001333
ORGANIZATION: NATIONAL CENTER FOR ENVIRONMENTAL HEALTH
OPDIV: CDC
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: HEALTH SERVICES
PERIOD OF PERFORMANCE START DATE: 09/30/2020
PERIOD OF PERFORMANCE END DATE: 09/29/2023

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Enhancing Disease Detection in Newborns: Building Capacity in Public Health Laboratories - The goal of Enhancing Disease Detection in Newborns: Building Capacity in Public Health Laboratories (CDC-RFA-EH20-2004) is to assist states and territories in implementing newborn screening for conditions that are part of the Recommended Uniform Screening Panel (RUSP). Our application focuses on supporting the North Carolina newborn screening program, within the North Carolina State Laboratory of Public Health, in their implementation of screening for Pompe, mucopolysaccharidosis, X-linked adrenoleukodystrophy, and spinal muscular atrophy. Our activities will include improving educational and outreach materials, helping select and implement testing methodologies, determining cutoffs, assisting with the transition to a new laboratory information management system, and improving reporting procedures. The application will also target improvements in data analytics and visualization to drive data-based decision-making. The focus of our work will be on Strategy A (Build newborn screening laboratory capacity to screen for new U.S. RUSP conditions) and Strategy C (Improve state laboratories’ ability to interpret newborn screening test results). For Strategy A, we will build capacity at the pre-analytic, analytic, and post-analytic phases of screening. This work will involve the newborn screening laboratory staff, as well as outreach to hospitals and birthing centers and coordination with follow-up staff and clinicians. This work will lead to Short-term Outcome 1: Full implementation of one or more newborn screening conditions recently added to the U.S. RUSP. For Strategy C, we will work with newborn screening laboratory and follow-up staff to improve the laboratory information management system and data handling and interpretation pipelines for newly added as well as already-screened conditions. These improvements will result in Short-term Outcome 2: Improved data processing, data management, and data analysis in state newborn screening laboratories. Ultimately, these activities will result in the following Long-term Outcomes: (1) the North Carolina newborn screening program is better positioned to adapt to changing technologies and increased demand for public health newborn screening, (2) newborns are referred for appropriate treatment and management in a timely manner, (3) infant mortality due to conditions detected via public health newborn screening decreases, and (4) children diagnosed with rare disorders via public health newborn screening achieve appropriate developmental milestones.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$81,383 )
2024	2021	RESEARCH TRIANGLE INSTITUTE	3040 CORNWALLIS RD	DURHAM	NC	27709	DURHAM	USA	Laboratory Leadership, Workforce Training and Management Development, Improving Public Health Laboratory Infrastructure	02	2	8/2/2024	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	-$81,383
2024	2020	RESEARCH TRIANGLE INSTITUTE	3040 CORNWALLIS RD	DURHAM	NC	27709	DURHAM	USA	Laboratory Leadership, Workforce Training and Management Development, Improving Public Health Laboratory Infrastructure	02	2	8/2/2024	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = -$81,383

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	RESEARCH TRIANGLE INSTITUTE	3040 E Cornwallis Rd	Research Triangle Park	NC	27709	DURHAM	USA	Laboratory Leadership, Workforce Training and Management Development, Improving Public Health Laboratory Infrastructure	01	2	9/9/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2022	2020	RESEARCH TRIANGLE INSTITUTE	3040 E Cornwallis Rd	Research Triangle Park	NC	27709	DURHAM	USA	Laboratory Leadership, Workforce Training and Management Development, Improving Public Health Laboratory Infrastructure	01	2	9/9/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $423,900 )
2021	2021	Research Triangle Institute	3040 E Cornwallis Rd	Research Triangle Park	NC	27709	DURHAM	USA	Laboratory Leadership, Workforce Training and Management Development, Improving Public Health Laboratory Infrastructure	00	2	6/25/2021	NON-COMPETING CONTINUATION	$423,900
2021	2020	Research Triangle Institute	3040 E Cornwallis Rd	Research Triangle Park	NC	27709	DURHAM	USA	Laboratory Leadership, Workforce Training and Management Development, Improving Public Health Laboratory Infrastructure	00	2	6/25/2021	NON-COMPETING CONTINUATION	$0
2021	2020	Research Triangle Institute	3040 E Cornwallis Rd	Research Triangle Park	NC	27709	DURHAM	USA	Laboratory Leadership, Workforce Training and Management Development, Improving Public Health Laboratory Infrastructure	01	1	12/15/2020	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = $423,900

Issue Date FY: 2020 ( Subtotal = $423,900 )
2020	2020	Research Triangle Institute	3040 E Cornwallis Rd	Research Triangle Park	NC	27709	DURHAM	USA	Laboratory Leadership, Workforce Training and Management Development, Improving Public Health Laboratory Infrastructure	00	1	8/20/2020	NEW	$423,900
														Subtotal = $423,900

Grand Total All Awards = $766,417

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Enhancing Disease Detection in Newborns: Building Capacity in Public Health Laboratories

Award Number: NU88EH001333

ORGANIZATION: NATIONAL CENTER FOR ENVIRONMENTAL HEALTH

OPDIV: CDC

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: HEALTH SERVICES

PERIOD OF PERFORMANCE START DATE: 09/30/2020

PERIOD OF PERFORMANCE END DATE: 09/29/2023

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