Capacity Building Assistance (CBA) for HIV Prevention Programs to End the HIV Epidemic in the United States - Component D: Technical Assistance for High-Impact HIV Prevention Programs - Significant progress has been made in HIV biomedical interventions over the past decade. The Ending the HIV Epidemic (EHE) initiative has set national goals to reduce new HIV infections by 75% by 2025 and 90% by 2030. To effectively end the HIV epidemic in the United States, Health Departments and community-based organizations need to address barriers in HIV prevention, care, and treatment. Social determinants of health (SDOH) play a crucial role in influencing health outcomes and are a major factor contributing to health disparities among populations disproportionately affected by HIV. Achieving the goals of EHE and promoting health equity requires ongoing efforts to address historical and contemporary injustices, overcome economic and social obstacles to healthcare, and eliminate preventable health disparities. The California Prevention Training Center (CAPTC) has nearly 3 decades of experience working directly with a wide array of HIV providers in health departments (HDs) and community-based organizations (CBOs) settings. The CAPTC has been a national leader in delivering SDOH technical assistance, working with HDs and CBOs with identifying social and economic inequities that prevent priority populations from receiving culturally relevant HIV prevention, care, and treatment services. Under Component D, the CAPTC intends to streamline the delivery of CBA to strengthen the capacity of HDs and CBOs to assess and address programmatic challenges to effectively plan, integrate, implement, evaluate, and sustain HIV prevention programs. The CAPTC will collaborate with the CDC and the CBA Provider Network (CPN) to deliver technical assistance (TA) and services to the CDC-funded HIV prevention workforce, including health department staff, CBOs, clinicians, and community partners. Through collaboration, communication, and coordination, the CAPTC will focus on addressing Component D content areas and social determinants of health that contribute to inequities in HIV prevention, care, and treatment. The TA provided by the CAPTC aims to strengthen the capacity of CDC-funded HIV prevention programs and their local partners in identifying and addressing syndemic conditions such as viral hepatitis, sexually transmitted infections (STIs), mental health disorders, substance use, and disparities among priority populations. Additionally, the CAPTC will offer TA to help overcome challenges in monitoring and evaluation, aiming to improve the performance and effectiveness of CDC-funded HIV prevention programs. To ensure comprehensive capacity building assistance (CBA), the CAPTC will continue to build on its long history of working with other CBA providers to further enhance the skills of a multidisciplinary HIV workforce to achieve the goals of EHE and health equity. The CAPTC has established expertise in the specific strategies outlined in this focus area (Category D) and looks forward to continuing impeccable working relationships with CDC-funded HDs and CBOs and their partners to support their HIV prevention goals, including EHE response plans, throughout the funding cycle.