Capacity Building Assistance for HIV Prevention Programs to End the HIV Epidemic in the United States - The Latino Commission on AIDS (The Commission) is proud to present our application in response to CDC-RFA-PS-24-0020, Capacity Building Assistance (CBA) for HIV Prevention Program to End the HIV Epidemic in the United States, focusing on our proposed national Hands United/Manos Unidas (HUMU) CBA program under Component D: Technical Assistance for High-Impact HIV Prevention Programs. For over three decades, the Commission has been at the forefront of providing comprehensive CBA services, earning nationwide recognition. Since 2004, we have been delivering CDC-funded CBA to a range of organizations, including Community-Based Organizations (CBOs), Health Departments (HDs), and Healthcare Organizations (HCOs). Our commitment to excellence is reflected in our two flagship models: the CHANGE (Customized, Holistic, Analytical, Network-building, Grassroots, Evaluatory) Model and the Prioritizing Intersectional Values for Organizational Technical Assistance (PIVOT), both of which have been widely published and presented at major conferences. Our proposed program through Hands United/Manos Unidas (HUMU) aims to bolster the organizational capacity of CDC-funded organizations, both directly and indirectly, including CBOs, HDs, and other social service organizations. We specifically target areas such as navigation to services, recruitment, and providing Technical Assistance (TA) aligned with the four pillars of Ending the HIV Epidemic (EHE): diagnose, treat, prevent, and respond. To achieve our goals, we will implement at a minimum 5 NOFO required activities and 9 core CBA strategies and activities: 1. Customized Technical Assistance (TA): Our approach emphasizes tailored solutions based on the unique needs of each organization, as identified through our CHANGE and PIVOT models. 2. Support for Implementation: With CDC-certified MASTER trainers in various interventions and public health strategies, we are equipped to provide the necessary toolkit for successful program implementation. 3. Communication, Collaboration, and Coordination: We excel in developing and implementing annual CBA plans, utilizing our experience to foster effective communication, collaboration, and coordination among stakeholders. 4. Virtual Community of Practice: Our CBA mechanism has been adapted to include a virtual community of practice, ensuring capacity building and engagement across distances. 5. CBO Summit: Drawing on our extensive experience, we plan to host a CBO summit to share insights and best practices from over 15 CBA institutes. 6. Development and Clearance of TA Products: We have a robust portfolio of TA materials, cleared by the CDC, and are continuously developing new resources to expand our reach. 7. Continuous Improvement: Our Monitoring, Evaluation, and Learning (MEL) unit ensures our CBA deliverables are continuously refined and improved. 8. Post-Training Follow-Up: We are committed to providing ongoing support and follow-up activities to ensure the long-term success of our CBA programs. 9. Expedited TA for CDC-funded HDs implementing HIV cluster detection and responses. Through these approaches, we are confident our Hands United/Manos Unidas (HUMU) CBA program will play a pivotal role in advancing high-impact HIV prevention programs, reducing HIV infections, enhancing early care engagement among PLWH, and addressing HIV-related disparities across the United States.