The American Indian Cancer Foundation (AICAF) is a native-led 501(c)3 organization established in 2010 with a mission to eliminate the cancer inequities faced by American Indians and Alaska Native (AI/AN) people through prevention, early detection, treatment, and survivor support. AICAF operates within the belief that Native communities have the wisdom and the solutions to address cancer inequities but often seek organizational capacity, expert input, and resources. The Indigenous Cancer Solutions Coalition (ICS) proposes to bring the REACH program to Native communities in Oklahoma, including Oklahoma County and the surrounding areas. In Oklahoma, poverty rates for AI/AN populations are highly variable, with rates lower in Oklahoma County (20%) but much higher for children (23%) and single mothers (32%). By implementing the core strategies under Component A, AICAF and its key partner, Oklahoma City Indian Clinic, are committed to working alongside community partners to increase access to nutrition, physical activity, and expand commercial tobacco policies. As a national Native-led organization dedicated to addressing health disparities among AI/ANs, our comprehensive approach, strong partnerships with and for Native communities, and track record of culturally-engaged program implementation position us to successfully advance nutrition, physical activity, and reduce commercial tobacco use in the region of Oklahoma County, OK. AICAF is committed to reaching the AI/AN community of over 52,000 tribal citizens. The overall goal of this proposed project is to improve the health and wellness of Native people in a culturally responsive way.