The Great Lakes Inter-Tribal Epidemiology Center’s Public Health Infrastructure program will utilize Component A of the National Center for Chronic Disease Prevention and Health Promotion’s Tribal Epidemiology Centers Public Health Infrastructure (TECPHI) CDC-RFA-DP22-2206 award to strengthen public health infrastructure and capacity of the Great Lakes Inter-Tribal Epidemiology Center and the Tribes and Urban Indian clinics located in the Indian Health Service (IHS) Bemidji Area. Since 1996, GLITEC has been the Tribal Epidemiology Center serving the 34 federally recognized Tribes, four urban Indian clinics, and three IHS Service Units in the Indian Health Service designated Bemidji Area (Michigan, Minnesota, Wisconsin, and Chicago). In the three states combined, in 2018, the AI/AN population amounted to over 340,000 individuals. All Tribal/urban Indian communities will receive an invitation to participate in learning opportunities, technical assistance, and other GLITEC offerings. It is expected that most components of TECPHI will have an Bemidji Area-wide impact. This work will support community led efforts to effectively identify and address underlying social determinants of health, reduce persistent health disparities, and improve the overall health and wellbeing of AI/AN people in the Bemidji Area.