The Arkansas Department of Health (ADH) Comprehensive Cancer Control Section (CCC), BreastCare Program, Arkansas Central Cancer Registry (ACCR) and the Arkansas Cancer Coalition (ACC) provide the foundation for a strong collaboration of cancer programs and partners that results in a coordinated State-wide approach to inform policy, systems and environmental changes to decrease the cancer burden in Arkansas. Using funding from the grant opportunity, Cancer Prevention and Control Programs for State, Territorial, and Tribal Organizations, The Reaching Out! Arkansas? Approach to Cancer Prevention and Control project provides high quality breast and cervical cancer screening and navigation, especially to women in disparate populations, health systems change, a state-wide cancer coalition for implementation of the Arkansas State Cancer Plan. The goal of this project is to reduce cancer incidence and mortality, and increase survival and quality of life among those with cancer in Arkansas. The Arkansas Cancer Control Leadership Team and the ACC collaborate to decrease cancer incidence, morbidity and mortality in Arkansas by maintaining the Arkansas Cancer Plan and implementing evidence-based strategies and activities to promote primary prevention of cancer, support cancer early detection and address the needs of cancer survivors with special emphasis on health equity. ACCR provides surveillance data to inform methods to target hard to reach populations for screening and preventive programs, support policy changes, and evidence-based cancer prevention and control research.