The State of Alaska, Department of Health and Social Services, Division of Public Health, Section of Chronic Disease Prevention and Health Promotion submits this application to collaboratively address the burden of cancer in Alaska. Cancer has been the leading cause of death in Alaska since 1993, one among a growing number of states where cancer leads heart disease in overall mortality rates. The new funding opportunity announcement (FOA) CDC-FRA-DP17-1701 will provide funds to continue this critical program for the next project period.The Alaska Cancer Prevention and Control Program (CPCP) consists of three distinct components that each receives funding from the US Centers for Disease Control and Prevention (CDC). The Breast and Cervical Health Check (BCHC) program funded through the National Breast and Cervical Cancer Early Detection Program (NBCCEDP) began screening women in Alaska in 1995. The Alaska Cancer Registry (ACR) funded through the National Program of Cancer Registries (NPCR) began collecting cancer incidence and mortality on residents of Alaska in 1996. The Comprehensive Cancer Control Program (CCCP) received funding from the National Comprehensive Cancer Control Program (NCCCP) for planning in 2003 and implementation in 2007. These three programs provide the backbone for cancer prevention and control activities in Alaska through a wide network of partners and volunteers. The current project period funding for the Alaska CPCP ends on June 29, 2022. The Alaska CPCP is well poised to move the program forward with an emphasis on collaboration and coordination across all funded cancer programs will the ultimate goals of decreasing rates of cancer incidence and mortality for the residents of Alaska.