Monday, December 11, 2023 12/11/2023

Characterizing the Complications Associated with Therapeutic Blood Transfusions for Hemoglobinopathies

Award Number: NU58DD000002
ORGANIZATION: NATIONAL CENTER ON BIRTH DEFECTS AND DEVELOPMENTAL DISABILITIES (NCBDDD)
OPDIV: CDC
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: HEALTH SERVICES

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Therapeutic blood transfusions are essential for the management of individuals with thalassemia and sickle cell disease. However, complications arising from transfusions are a major cause of morbidity. The overall aim of this project is to enhance the appropriate use and safety of transfusions in hemoglobinopathies through education, surveillance, and promotion of consensus- or evidence-based guidelines. Information on the prevalence of thalassemia in the United States remains inadequate, which constrains efforts to improve access to expert management and continuity of care. Certain individuals who are not getting transfused may develop complications later in life that will require transfusions. This project will develop and validate a method for identifying previously undiagnosed individuals with thalassemia. This will achieve the outcome of improved understanding of the prevalence and natural history of thalassemia, which will assist in the rational use of transfusion therapy and improved quality of life of individuals with thalassemia. Hemoglobinopathies disproportionately affect individuals from minority populations. Donor-recipient mismatch of red cell antigens because of different ethnicities contributes to the high rate of alloimmunization observed in thalassemia and sickle cell disease. Alloimmunization is a serious complication that can jeopardize further transfusion therapy, but its prevalence may be lowered if donor-recipient red cell antigens are better matched. This project will develop processes to disseminate information pertaining to thalassemia and sickle cell disease that raises awareness of the need for blood donations from population groups most impacted by hemoglobinopathies. Increased diversity of the blood supply will be achieved through the outcome of higher proportion of donors from the minority communities. The extensive genotypic diversity of hemoglobinopathies necessitates complex laboratory testing protocols. The appropriate management of thalassemia and sickle cell disease and the rational use of transfusions will be facilitated by improved understanding of the laboratory results. In order to achieve this outcome, a toolkit of educational materials will be developed to interpret laboratory results that indicate a potential or confirmed diagnosis of thalassemia or sickle cell disease. The target populations are individuals affected by thalassemia and sickle cell disease, their families and caretakers, and health care providers in primary and specialty-care setting. The adoption of standardized guidelines to manage transfusion therapy of individuals with thalassemia and sickle cell disease will reduce the prevalence of complications. This outcome will be achieved through an increased understanding of the guidelines for management of transfusions in hemoglobinopathies. This project will develop a toolkit of educational materials on evidence- or consensus-based guidelines for the management of transfusions. The target populations are blood bank administrators and transfusion medicine providers, individuals with thalassemia and sickle cell disease, their families and caretakers, and their health care providers. Since the exposure to blood transfusions in individuals with hemoglobinopathies is recurring and indefinite, the risk of transfusion-associated infections is significant. This project will achieve the outcome of understanding how infectious agents play a role in transfusion complications in thalassemia and sickle cell disease through the collection of biological specimens over the project period for testing. The multi-faceted activities and outcomes in this project will address critical areas in transfusion management that will lead to a decreased occurrence of complications and an improvement in the quality of life for individuals with thalassemia and sickle cell disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $250,000 )
2023	2023	Regents of the University of California, San Francisco, The	1855 Folsom St Ste 425	San Francisco	CA	94143	SAN FRANCISCO	USA	Blood Disorder Program: Prevention, Surveillance, and Research	00	5	6/11/2023	NON-COMPETING CONTINUATION	$250,000
2023	2022	Regents of the University of California, San Francisco, The	1855 Folsom St Ste 425	San Francisco	CA	94143	SAN FRANCISCO	USA	Blood Disorder Program: Prevention, Surveillance, and Research	00	5	6/11/2023	NON-COMPETING CONTINUATION	$0
2023	2021	Regents of the University of California, San Francisco, The	1855 Folsom St Ste 425	San Francisco	CA	94143	SAN FRANCISCO	USA	Blood Disorder Program: Prevention, Surveillance, and Research	00	5	6/11/2023	NON-COMPETING CONTINUATION	$0
2023	2020	Regents of the University of California, San Francisco, The	1855 Folsom St Ste 425	San Francisco	CA	94143	SAN FRANCISCO	USA	Blood Disorder Program: Prevention, Surveillance, and Research	00	5	6/11/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $250,000

Issue Date FY: 2022 ( Subtotal = $250,000 )
2022	2022	Regents of the University of California, San Francisco, The	1855 Folsom St Ste 425	San Francisco	CA	94143	SAN FRANCISCO	USA	Blood Disorder Program: Prevention, Surveillance, and Research	00	4	6/6/2022	NON-COMPETING CONTINUATION	$250,000
2022	2021	Regents of the University of California, San Francisco, The	1855 Folsom St Ste 425	San Francisco	CA	94143	SAN FRANCISCO	USA	Blood Disorder Program: Prevention, Surveillance, and Research	00	4	6/6/2022	NON-COMPETING CONTINUATION	$0
2022	2021	Regents Of The University Of California, San Francisco, The	1855 Folsom St Ste 425	San Francisco	CA	94143	SAN FRANCISCO	USA	Blood Disorder Program: Prevention, Surveillance, and Research	01	3	1/6/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2022	2020	Regents of the University of California, San Francisco, The	1855 Folsom St Ste 425	San Francisco	CA	94143	SAN FRANCISCO	USA	Blood Disorder Program: Prevention, Surveillance, and Research	00	4	6/6/2022	NON-COMPETING CONTINUATION	$0
2022	2020	Regents Of The University Of California, San Francisco, The	1855 Folsom St Ste 425	San Francisco	CA	94143	SAN FRANCISCO	USA	Blood Disorder Program: Prevention, Surveillance, and Research	01	3	1/6/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = $250,000

Issue Date FY: 2021 ( Subtotal = $249,438 )
2021	2021	Regents Of The University Of California, San Francisco, The	1855 Folsom St Ste 425	San Francisco	CA	94143	SAN FRANCISCO	USA	Blood Disorder Program: Prevention, Surveillance, and Research	00	3	6/8/2021	NON-COMPETING CONTINUATION	$249,438
2021	2020	Regents Of The University Of California, San Francisco, The	1855 Folsom St Ste 425	San Francisco	CA	94143	SAN FRANCISCO	USA	Blood Disorder Program: Prevention, Surveillance, and Research	00	3	6/8/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $249,438

Issue Date FY: 2020 ( Subtotal = $250,000 )
2020	2020	Regents Of The University Of California, San Francisco, The	1855 Folsom St Ste 425	San Francisco	CA	94143	SAN FRANCISCO	USA	Blood Disorder Program: Prevention, Surveillance, and Research	00	2	6/25/2020	NON-COMPETING CONTINUATION	$250,000
2020	2019	Regents Of The University Of California, San Francisco, The	1855 Folsom St Ste 425	San Francisco	CA	94143	SAN FRANCISCO	USA	Blood Disorder Program: Prevention, Surveillance, and Research	01	1	12/31/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = $250,000

Issue Date FY: 2019 ( Subtotal = $250,000 )
2019	2019	Regents of the University of California, San Francisco, The	1855 Folsom St Ste 425	San Francisco	CA	94143	SAN FRANCISCO	USA	Blood Disorder Program: Prevention, Surveillance, and Research	00	1	7/19/2019	NEW	$250,000
														Subtotal = $250,000

Grand Total All Awards = $1,249,438

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Characterizing the Complications Associated with Therapeutic Blood Transfusions for Hemoglobinopathies

Award Number: NU58DD000002

ORGANIZATION: NATIONAL CENTER ON BIRTH DEFECTS AND DEVELOPMENTAL DISABILITIES (NCBDDD)

OPDIV: CDC

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: HEALTH SERVICES

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