Cooperative Agreement for TB Prevention and Control for the State of Iowa. - The Iowa Tuberculosis Program provides administrative and clinical guidance to all 99 local public health agencies (LPHAs) in Iowa. This includes direct oversight of the management of LTBI and active TB disease cases. The Program provides clinical consultation, education and training to providers and LPHAs throughout Iowa. The TB Control Program utilizes federal funding to employ a TB Nurse Consultant and a TB Program Manager. These two positions serve as the subject matter experts on all aspects of TB Control in Iowa. The TB Program Manager and the TB Nurse Consultant are responsible for assuring all patients with LTBI and TB disease are properly diagnosed and prescribed the most effective TB regimen for their individual case. Due to a sustained surge in TB disease case numbers, complex TB disease cases and overall strain on current TB staff, the Program hired a second TB Nurse Consultant in July of 2024. The TB Control Program provides incentive funding for DOT and medical evaluation services to all 99 local public health agencies on a needed and contractual basis. The Program provides medications for all persons diagnosed with either LTBI or TB disease in Iowa. The mission of the Iowa TB Control Program is to eliminate TB in Iowa. Elimination of TB in Iowa is predicated on the implementation of three (3) priority strategies for controlling and preventing TB, as recommended by the Advisory Council for the Elimination of Tuberculosis (ACET) that include: (1) identifying and fully treating persons who have active TB disease; (2) finding and screening persons who are contacts to TB cases to determine if they are infected with Mycobacterium tuberculosis or have active TB, and providing appropriate treatment; and (3) targeting populations at high-risk for infection and disease to detect infected persons and provide TB infection (TBI) therapy when appropriate to prevent progression to active TB. The Iowa TB Control Program is committed to progressing to toward the national targets set forth in the National TB Indicators Project (NTIP). Deficiencies in the NTIP Indicators will be addressed to achieve maximum outcomes. The Program prioritizes the evaluation of exposed contacts to infectious cases of TB disease and emphasizes the completion of LTBI TX for these contacts. The Program likewise places priority to identifying, testing and treating those Iowans most at risk of having LTBI and progressing to TB disease if untreated. This includes the increasing population of immigrants from the Marshall Islands and the Federated States of Micronesia. The Iowa TB Program is applying for funding under the Tuberculosis Elimination and Laboratory Cooperative Agreement CDC-RFA-PS-25-0003 to assist with addressing the strategies and implementing the activities identified in this application. Funding for Prevention and Control (P&C) and for Laboratory Strengthening will allow for continued and new activities that be measured by evaluation of progress toward short-term and intermediate outcomes outlined in the funding announcement. Progress toward these short-term and intermediate outcomes will lead to a decreased TB incidence overall and among those populations at higher risk and those disproportionately affected by TB disease and TB infection.