West Virginia CDC-RFA-PS-25-0003 - The West Virginia Tuberculosis (TB) Elimination Program (WV-TBEP) provides programmatic oversight, clinical services, guidance and consultation, education, training and resources to all 55 local health departments throughout West Virginia for TB patients. The WV-TBEP utilizes federal funding in conjunction with state funding for basic public health services as well as categorical funding for specific TB programs. Local health departments provide direct patient care for TB patient under guidance from WV-TBEP medical director and programmatic staff. WV-TBEP supports these activities through both direct and in-kind materials and services The mission of the WV-TBEP is to eliminate TB in West Virginia. Elimination of TB in West Virginia is predicated on the implementation of three (3) priority strategies for controlling and preventing TB, as recommended by the Advisory Council for the Elimination of Tuberculosis (ACET) that include: (1) identifying and fully treating persons who have active TB disease; (2) finding and screening persons who are contacts to TB cases to determine if they are infected with Mycobacterium tuberculosis or have active TB, and providing appropriate treatment; and (3) targeting populations at high-risk for infection and disease to detect infected persons and provide TB infection (TBI) therapy when appropriate to prevent progression to active TB. The WV-TBEP is committed to progressing toward the national targets set forth in the National TB Indicators Project and strive to develop evaluation strategies to address those indicators not being met. In addition, the TTBEP is committed to identifying, screening, testing, and treating those individuals at high risk for exposure to Mycobacterium tuberculosis, those at high risk for progression to active TB disease if exposed, and those populations experiencing health disparities and disproportionately affected by TB disease and TB infection (TBI). The WV-TBEP is applying for funding under the Tuberculosis Elimination and Laboratory Cooperative Agreement CDC-RFA-PS-25-0003 to assist with addressing the strategies and implementing the activities identified in this application. Funding for Prevention and Control (P&C) and for Laboratory Strengthening will allow for continued and new activities that be measured by evaluation of progress toward short-term and intermediate outcomes outlined in the funding announcement. Progress toward these short-term and intermediate outcomes will lead to a decreased TB incidence overall and among those populations at higher risk and those disproportionately affected by TB disease and TB infection.