Philadelphia: TB Elimination and Laboratory Program Funding. - Project Abstract The Philadelphia Department of Public Health Tuberculosis Control Program (TBC) and TBC’s Flick Clinic provide high quality clinical services to those living with and at risk for tuberculosis, including pediatric patients. TBC ensures that the care for TB patients does not stop once they leave the clinic. TBC Field Staff conduct DOT, patient interviews, contact elicitation, among a variety of other services to promote treatment adherence and eventual completion. Surveillance and Epidemiology provide reliable and accurate data reporting to the CDC and to other TBC staff to ensure that every patient is being attended to. TBC utilizes federal funding to facilitate staffing and the above program activities. The mission of the TBC is to eliminate TB in Philadelphia. Elimination of TB in Philadelphia is predicated on the implementation of three (3) priority strategies for controlling and preventing TB, as recommended by the Advisory Council for the Elimination of Tuberculosis (ACET) that include: (1) identifying and fully treating persons who have active TB disease; (2) finding and screening persons who are contacts to TB cases to determine if they are infected with Mycobacterium tuberculosis or have active TB, and providing appropriate treatment; and (3) targeting populations at high-risk for infection and disease to detect infected persons and provide TB infection (TBI) therapy when appropriate to prevent progression to active TB. TBC is committed to progressing toward the national targets set forth in the National TB Indicators Project. Our efforts focus on developing a robust evaluation strategy to address those indicators not being met. Furthermore, TBC is committed to identifying, screening, testing, and treating those individuals at high risk for exposure to Mycobacterium tuberculosis, those at high risk for progression to active TB disease if exposed, and those populations experiencing health disparities and disproportionately affected by TB disease and TB infection (TBI). TBC is seeking funding through the Tuberculosis Elimination and Laboratory Cooperative Agreement CDC-RFA-PS-25-0003 to support the implementation of the strategies and activities outlined in this application. This funding will enable both ongoing and new Prevention and Control (P&C) initiatives, as well as Laboratory Strengthening activities. Progress will be measured against short-term and intermediate outcomes specified in the funding announcement. Achieving these outcomes will ultimately lead to a reduction in TB incidence overall, particularly among high-risk and disproportionately affected populations.