Tuberculosis Elimination and Laboratory Cooperative Agreement - Mississippi State Department of Health (MSDH) mission is to protect and advance the health, well-being and safety of everyone in Mississippi. Achieving this mission is predicated on the implementation of three (3) priority strategies for controlling and preventing TB as recommended by the National Advisory Council for the Elimination of Tuberculosis (ACET): 1. Identification and completion of treatment for persons with active Tb disease to render their condition noninfectious. 2. Finding and screening persons who have had contact with persons with active TB disease to determine: whether they have active TB themselves; whether they have been infected with Mycobacterium tuberculosis; or for children and other persons at high risk whether they require window prophylaxis (preventive treatment of presumed TB infection during the time that it would take for a tuberculin skin test [TST] or interferon gamma release assay [IGRA] to become positive after exposure) and whether to administer treatment; and 3. Screening, testing, and treatment of other selected persons and populations at high risk for TB infection (TBI) and subsequent active TB disease to detect persons who can most benefit from treatment for TBI, which is essential for TB elimination because of new immunosuppressive drugs and therapies used for different illnesses, immigration from areas where TB is endemic, and diminished knowledge and reduced recognition of TB by clinicians as a result of decreased incidence.