Tuberculosis Elimination and Laboratory Cooperative Agreement - The South Carolina Department of Public Health’s (DPH’s) Tuberculosis (TB) Control Section protects residents from TB through case finding, treatment, contact investigations, and targeted testing. DPH is a centralized public health system in which the state office provides oversight and funding to each of the four regions within South Carolina (SC). Each region has a TB team that covers an 11-12 county territory. TB Control’s mission is to eliminate TB in SC. Elimination of TB in SC is predicated on the implementation of three (3) priority strategies for controlling and preventing TB, as recommended by the Advisory Council for the Elimination of Tuberculosis (ACET) that include: (1) identifying and fully treating persons who have active TB disease; (2) finding and screening persons who are contacts to TB cases to determine if they are infected with Mycobacterium tuberculosis or have active TB, and providing appropriate treatment; and (3) targeting populations at high-risk for infection and disease to detect infected persons and provide latent TB infection (LTBI) therapy when appropriate to prevent progression to active TB. TB Control is committed to progressing toward the national targets set forth in the National TB Indicators Project (NTIP). Evaluation strategies will be set forth to address indicators that are not being met, and remediation plans will be put into place. DPH’s TB Control Section is applying for funding under the Tuberculosis Elimination and Laboratory Cooperative Agreement CDC-RFA-PS-25-0003 to assist with addressing the strategies and implementing the activities identified in this application. Funding for Prevention and Control (P&C), Human Resource and Development (HRD) and Laboratory Strengthening will allow for continued and new activities to address progress towards TB Elimination, as outlined in the logic model set forth in the funding announcement.