The purpose of this application is for the Acute Disease Service Tuberculosis (TB) Division and the Public Health Laboratory (PHL) of the Oklahoma State Department of Health to acquire Centers for Disease Control and Prevention (CDC) funding for Prevention and Control, Human Resource Development, and Public Health Laboratory Strengthening activities to address TB in Oklahoma. Oklahoma’s target problem is the treatment initiation of infected contacts for the reduction of future TB disease. For this five-year grant period, the TB Division will continue to work toward detecting TB cases, perform aggressive contact investigations, identify and educate those infected, provide TB treatment and preventive TB treatment for high-risk persons to reduce the incidence of active TB disease in Oklahoma. The PHL will work toward reducing turnaround time for culture and NAA results and increasing the proportion of who have initial drug-susceptibility results reported and who have a MTBC genotyping result reported for TB patients with a positive culture. The TB Division is determined to utilize the known, valid science to reduce morbidity and mortality caused from TB and is dedicated to achieve all of the NTIP and performance targets, located at https://www.cdc.gov/tb/programs/evaluation/indicators/default.htm. The TB Division and PHL plan to conduct these activities for the period of January 1, 2020 through December 31, 2024 and the efforts throughout the grant period will help to achieve the goal to decrease TB case rates and TB infection in the United States by 2025.