Epidemiology & Laboratory Capacity for Prevention & Control Of Emerging Infections (ELC) - New Mexico (NM) has a diverse population of 2,117,292 according to NM’s Indicator-based Information System (NM-IBIS) 2020 estimates. American Indian and Alaska Natives make up 9% of the population and 50% of the population are persons of Hispanic or Latino origin. New Mexico is a geographically large, predominately rural and frontier “majority-minority” state that shares a border with Mexico. New Mexico has a centralized Department of Health (NMDOH) without local health offices. The Epidemiology and Laboratory Capacity (ELC) grant funds public health action throughout the state. The main ELC beneficiaries at NMDOH are the Epidemiology and Response Division, the Scientific Laboratory Division (SLD, state public health laboratory) and to a lesser degree the Public Health Division (PHD, staffs local public health offices/clinics). The New Mexico Department of Health proposes to conduct activities in the following areas: Section I: Cross-cutting Emerging Infectious Disease Capacity, Systems, and Leadership Program A: Cross-cutting Epidemiology and Laboratory Capacity Project B: ELC Leadership, Management, and Administration Project C: Health Information System (HIS) Capacity Project D: Advanced Molecular Detection (AMD) Project E: National Wastewater Surveillance System Project F: Emerging Issues Section II: Emerging Infectious Disease Programs Program G: Enteric, Foodborne, Waterborne, and Zoonotic Diseases: Surveillance, Detection, Response, Reporting, and Prevention Program H: Healthcare-associated Infections, Antimicrobial Resistance, and Antibiotic Stewardship Program I: Antimicrobial Resistance Laboratory Network (AR Lab Network) Program J: Enhanced Surveillance for Vaccine-Preventable Disease (VPD) and Respiratory Diseases Program K: Vector-borne Diseases and Tick-Associated Conditions Section III: Disease-Specific Projects Project M: Mycotics: Detecting and Preventing Fungal Infections Project N: Binational Border Infectious Disease Surveillance (BIDS) Project Q: Combating Antimicrobial Resistant Gonorrhea and Other STIs (CARGOS) Project R: Rabies Surveillance and Laboratory Capacity Program funding will be spent in accordance with the grant guidance. Project-specific performance measures are proposed to monitor grant-related activities.