In this proposal, the California Department of Public Health (CDPH), the University of California, Berkeley School of Public Health (UCB-SPH), selected local and county health departments, and other partners request an additional five years of support for the California Emerging Infections Program (EIP), which was established in 1994 with support from the Centers for Disease Control and Prevention and has been re-funded four times since then. We propose to maintain core disease surveillance and response capabilities and to implement or continue data modernization efforts with the active bacterial core surveillance and related activities (ABCs); active population-based laboratory surveillance for foodborne diseases and related activities (FoodNet); influenza and RSV infections resulting in hospitalization; population-based surveillance for hospitalizations resulting from laboratory-confirmed SARS-CoV-2, (RESP-Net); surveillance for and related studies of healthcare-associated infections (HAI) and antimicrobial resistance; surveillance for HPV infection and related studies of the impact of HPV vaccine (HPV-Impact); surveillance for prion disease, myalgic encephalomyelitis/ chronic fatigue syndrome (ME/CFS) and ME/CFS-like Post-COVID conditions, and the Mpox vaccine effectiveness evaluation as well as maintain surge capacity that can assist in flexible responses to newly emerging infectious disease threats and participate in rapid population surveys. In addition, we propose to continue to provide appropriate isolates and/or specimens to CDC; collaborate with CDC and other EIP sites in the management, analysis, interpretation, and publication of data from EIP projects; provide training to working public health professionals, students, and fellows; participate in an exchange program; act as a resource for states and other parts of California without EIPs; and ensure review of various EIP projects by appropriate institutional review boards whenever ne
cessary (for current IRB approvals see Appendix X). The California EIP will continue to be administered by Public Health Foundation Enterprises, Inc., based in the City of Industry, California.