In recent years, emerging (e.g., Ebola, SARS) and re-emerging infectious diseases (e.g., measles) have tested public health system capacity at every response level, with COVID-19 bringing greater attention to the state of our fragmented public health infrastructure. The National Network of Public Health Institutes (NNPHI) is the official organization that represents more than 40 member public health institutes, affiliate members and emerging institutes in more than 30 states spanning all ten Department of Health and Human Services regions. NNPHI is also the home of the National Coordinating Center for Public Health Training (NCCPHT), convening a network of 10 university-based regional public health training centers (RPHTCs) located at accredited schools of public health and 40 local education sites. Through the rapid deployment of our distributive capacity network of public health institutes and public health training centers, NNPHI will implement its Preventing and Controlling Emerging Infectious Diseases Initiative (“PCEID Initiative”). The PCEID Initiative will provide critical process and content expertise to support the Health Strategist workforce in preventing and controlling emerging and re-emerging infectious diseases. NNPHI will inform and adapt guidance, as well as develop training, in order to prevent and control emerging and re-emerging infectious diseases. In strengthening the U.S. public health system response to emerging and re-emerging infectious diseases, NNPHI expects to see positive outcomes including the development of new existing infectious disease prevention and control resources, and increasing the number of health workers who are trained and understand best practices for the prevention and control of emerging infectious diseases.