The Oklahoma State Department of Health (OSDH) continues to build its public health infrastructure to detect, monitor, investigate, and control multiple infectious disease threats, including enteric diseases, vaccine-preventable diseases, influenza, other viral respiratory pathogens, healthcare-associated infections, and vector-borne diseases. The funds from this new cooperative agreement will support the work of multiple OSDH epidemiologists and laboratorians to address cross-cutting programmatic issues as well as focus on discrete projects aimed at improving disease surveillance, investigation, and outbreak capacity. Funding support will be used to purchase laboratory testing supplies and equipment in the Public Health Laboratory and provide travel and training for staff to maintain competency on new laboratory technologies, including advanced molecular detection. Funding will also be utilized to obtain contractual work to enhance electronic health information systems, expert guidance on healthcare-associated infection consultations, train healthcare professionals on antimicrobial stewardship, expand syndromic surveillance to strategic areas of the state, and expand ecologic surveillance activities. The goal of program activities and focused projects is to reduce the morbidity and mortality of infectious disease threats in the state of Oklahoma.