Public Health Partnerships to Accelerate Prevention and Control of Infectious Diseases and Emerging Public Health Threats in China and Globally - Recognizing that the international spread of disease is a global threat with serious consequences for lives, livelihoods, societies and economies that calls for the widest possible international and regional collaboration, cooperation and solidarity with all people and countries in order to ensure an effective, coordinated, appropriate, comprehensive and equitable international response. With the support of the U.S. Centers for Disease Control and Prevention (CDC), considerable achievements have been made in the areas of emerging and re-emerging infectious diseases prevention and control. This 5-year proposal includes joint investigations and monitoring of disease outbreaks, piloting innovative public health interventions, translating programmatic success to practice and policy, working in third countries to jointly respond to public health emergencies, and promoting rapid and transparent dissemination of public health practice. This proposal will strive to collaborate China CDC with CDC, including third countries and UN agencies to share knowledge and evidence-based science for a bilateral and multilateral exchange that mutually benefits the U.S.A and China through partnership that builds sustainable expertise and capacity in global health security and public health systems. The Program management office plays the vital role of coordinating, planning, implementing, and monitoring and evaluation for the overall project. The main strategies and activities are as follows. Component 1: Strengthen public health systems and workforce capacity. The activities aim to strengthen the public health workforce and related systems to effectively prevent, detect, and respond to public health threats. The priorities include to strengthen the workforce capacity to rapidly detect, prevent, and respond to disease clusters of known and unknown and other public health emergency events, with a focus on rapid response team deployment, to build workforce capacity and establish protocols and procedures within the incident command structure, to enhance the reporting and dissemination of timely, accurate, and relevant public health information, and to increase coordination and collaboration between China CDC and U.S.CDC in jointly responding to public health emergencies in third countries for strengthening collaboration among international partners. Component 2: Decrease the burden of TB. The activities are to implement performance quality management interventions in health care settings in China, and to exchange applicable and sustainable practices, lessons learned, and evidence-based science with CDC and international counterparts. In the context, it is prioritized to improve infection prevention and control in health care settings, to strengthen laboratory systems to improve TB diagnosis and to employ intensive close contact screening and preventive treatment in Zero TB communities. Component 3: Reduce the influenza morbidity and mortality and enhance preparedness for pandemic threats. The activities facilitate the prevention and detection of seasonal and novel influenza, with aiming at establishing multi-sectoral partnerships for early detection and timely investigation of avian and novel influenza, to promote the use of vaccines, antivirals, and non-pharmaceutical interventions in high-risk groups , to conduct the optimized respiratory multi-pathogens surveillance strategy and surveillance data for public health action. Components 4 and 5: Rapid response to small-scale and large-scale public health emergencies. In the context of third countries, the activities include to support and optimize the local surveillance, to explore the programmatic and optimized mechanism of PABS and culture collection with pandemic potential, to develop/implement partnership mechanisms for a more robust and responsive global health emergency workforce, to intensify social mobilization, community engagement, and to restore priorities of public health system.