Colorado Collaborative to Address Birth Defects - The Colorado Department of Public Health, together with the University of Colorado Anschutz Medical Campus, propose to enhance partnerships to address birth defects, infant disorders and related conditions by: 1) improving the quality and use of data and data collection and dissemination systems and tools, and 2) rebuilding and enhancing statewide collaborations. Colorado proposes to strengthen connections with clinical, community, and public health partners who focus on improving the lives of those living with birth defects, infant disorders and related conditions. This collaboration will also serve to provide feedback for the modernization of data collection and systems/processes that will ensure the data is easily accessible and used to guide the direction of clinical, community and population health with a strong focus on identifying and strategically addressing Colorado’s unique attributes and health inequities. As guided by the funding opportunity CDC-RFA-DD-23-0004, Colorado will implement activities to improve the collection and translation of data (Strategy 1), and enhance partnerships (Strategy 5) across the state. The proposed strategies and activities will increase the availability of data to inform clinical care and public health materials, messaging, resources, and interventions, and improve information sharing and/or coordination among networks. These initial outcomes will position Colorado to have increased awareness and use of data-informed clinical care and public health materials, messaging, resources, and interventions. This work will propel Colorado towards the longer term goals of improved clinical and public health approaches, improved public health and clinical outcomes, and decreased health disparities among those living with birth defects, infant disorders and related conditions.