Illinois Department of Public Health Abstract Illinois has a large, diverse population; 128,435 resident live births and 690 stillbirths are currently recorded for 2022. Illinois Department of Public Health (IDPH) began state-wide surveillance of adverse pregnancy outcomes in 1989 with the establishment of the Adverse Pregnancy Outcome Reporting System (APORS). Pregnancy outcomes include live births and stillbirths. APORS has a two-fold purpose: 1) collection of adverse pregnancy outcomes for surveillance, policy development and epidemiologic studies; and 2) referral of high-risk newborns for community-based medical and social follow-up services. Recent public health concerns – the spread of the Zika and SARS-CoV-2 viruses and increasing opioid use – have reinforced the importance of surveillance systems to be able to respond quickly and efficiently. APORS’s broad case definition and flexible database has allowed APORS to collaborate with the Centers for Disease Control and Prevention (CDC) and March of Dimes in evaluating the impact of these concerns on parent and child health. This funding will allow APORS to improve and expand longitudinal surveillance of stillbirths, neonatal abstinence syndrome, prenatal cannabis exposure, congenital syphilis, Hepatitis B and C, and CMV in pregnant people-infant dyads. APORS will identify potential cases, using multiple data sources, and will abstract medical records for pregnancy people-infant dyads. Surveillance data will be submitted to CDC and analyzed to provide information about the impact of these conditions during on pregnancy people and their infants. Information will be disseminated widely. APORS will also remain ready to undertake surveillance of new and emerging conditions that impact pregnant people, infants, and children. APORS’ intended outcomes are to: 1) ensure the availability of timely, high-quality, modern, and efficient surveillance data for these key exposures and outcomes that impact
pregnant people, infants, and children; and 2) Improve public health strategies, innovate clinical recommendations, and identify novel findings for the key and exposures and outcomes affecting pregnant persons and their infants.