The City of Hartford, Connecticut Department of Health and Human Services proposes to used OD2A: LOCAL funds to support the transformation of the Hartford OD2A Collaborative Improvement & Innovation Network (CoINN) to include three local health districts covering 14 additional towns. A CoIIN is a multi-disciplinary team of diverse federal, state, local leaders, subject matter experts, stakeholders, and persons with lived experience who work together to solve a common problem, often one that involves complex social determinants of health (SDOH) and health disparities. The CoIIN process will establish a structured workspace to facilitate collaborative learning, continuous quality improvement, and innovation in response to overdose and unintentional overdose death patterns that result in a significant number of adverse events occurring within Hartford to non-Hartford residents. Project funds will support prevention activities (Component A), toxicologic testing of drug product and paraphernalia (Component B, not M/E), and surveillance of linkage to and retention in care (Component C). The CoINN model supports a data-to-action approach and embeds an evaluator directly into the process. The approach will improve surveillance capacity, improve coordination of resources in response to community need, and scale best practices across multiple local health districts - including alignment with OD2A: STATE activities and systems. The Greater Hartford OD2A CoIIN anticipates a 3%-5% average yearly reduction in unintentional overdoses and overdose-related deaths, over the course of the program. Ultimately, the approach will result in an anticipated 15% - 25% reduction in unintentional overdoses and overdose-related deaths over the course of the program.