CDC-RFA-IP-25-0007 Strengthening Vaccine Preventable Disease Prevention and Response - Strengthening Vaccine-Preventable Disease Prevention and Response Maine Project Abstract Maine’s unique demographic and geographic characteristics present distinct challenges in public health service delivery, particularly in vaccine accessibility and immunization efforts. The Maine Immunization Program (MIP), housed within the Maine Centers for Disease Control (Maine CDC), is dedicated to strengthening vaccine-preventable disease prevention and response through enhanced outreach, education, and access initiatives. Despite progress in childhood immunization rates—exceeding the 95% herd immunity threshold as of the 2023-2024 school year—barriers such as misinformation, vaccine hesitancy, and logistical constraints persist. MIP’s strategic objectives focus on expanding vaccine access, improving immunization rates, reducing misinformation, and supporting communities with lower vaccination rates. Key strategies include bolstering program infrastructure, expanding community outreach, implementing targeted public education campaigns, and fostering strong collaborations with healthcare providers and stakeholders. A significant component of MIP’s future efforts involves developing a universal adult immunization program, ensuring equitable vaccine access for individuals over 19 while reducing healthcare costs. To measure impact, MIP will implement a comprehensive evaluation plan incorporating both qualitative and quantitative data, leveraging the Immunization Information System (IIS) and epidemiological analysis to refine strategies and enhance program effectiveness. Through sustained funding, MIP aims to safeguard public health by ensuring vaccine accessibility, countering misinformation, and maintaining high immunization rates across Maine. Strengthening partnerships with state, regional, and national organizations will further enhance the state’s capacity to prevent vaccine-preventable diseases and protect its residents for years to come.