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Exploring the role of Hedgehog pathway-Primary cilia axis in human lung alveologenesis and disease

Award Number: K99HL177341
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 08/01/2025
PERIOD OF PERFORMANCE END DATE: 07/31/2027

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Exploring the role of Hedgehog pathway-Primary cilia axis in human lung alveologenesis and disease - Project Summary/ Abstract Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease of prematurity, characterized by defective gas exchange area, due to reduced alveolar surface. The alveolar epithelium is composed of squamous alveolar epithelial type 1 cells (AT1), which cover more than 90% of the alveolar surface, and cuboidal alveolar epithelial type 2 (AT2) cells that possess stem and progenitor cell capabilities as demonstrated by their ability to self-renew, maintain the AT2 pool, and differentiate into AT1 during alveolarization and following lung injury. The alveolar epithelium serves as a physical barrier against environmental stimuli. Alveolar formation in humans occur in utero and is regulated by multiple cellular and molecular processes, involving proliferation, differentiation, and epithelial-mesenchymal crosstalk. The Hedgehog (HH) pathway plays an important role in orchestrating these events and its deregulation can result in defective lung development, thus leading to diseases such as BPD. Aberrant HH signaling is implicated in BPD as well as various adult lung diseases, such as asthma and COPD. We recently described that the HH signaling plays an important role in early human lung development. The HH pathway ligand, Sonic Hedgehog (SHH) regulates progenitor cell interactions in the airway and alveolar compartments during lung development. Our previously generated scRNAseq data demonstrate a continuous increase of SHH expression during human lung development. Additionally, the HH pathway activator (PTCH1) is highly expressed during early lung development, coinciding with the expansion of the progenitor cell pool, while the inhibitor (HHIP) is highly expressed during progenitor differentiation. These observations suggest that early activation of the HH pathway is essential in early lung development, whereas its inhibition promotes alveologenesis. The HH pathway is regulated by sensory organelles, called primary cilia (PC), which play an important role in the transduction of the HH signaling. The presence and proper function of PC are known to be essential for the activation and modulation of the HH pathway during various stages of lung development. We recently demonstrated a dysregulation of the HH pathway and PC in COPD, and our preliminary data suggest disruption of these elements in BPD. Therefore, we hypothesize that a HH/primary cilia signaling axis is crucial during alveologenesis, facilitating the maturation of AT2 cells. To test this hypothesis, we will 1) Investigate the role of HH signaling in the maturation of alveolar epithelial cells (K99), 2) Investigate the interaction between PC and HH signaling in alveologenesis (K99/R00), and 3) Assess the interplay between the HH pathway and PC in BPD (R00). The proposed career development plan is designed to equip the PI with unique skill sets, expand knowledge base and research experience to becoming a productive and independent investigator researcher in the field of lung biology, alveologenesis and BPD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $156,168 )
2025	2025	LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER	1124 W CARSON ST BLDG MRL	TORRANCE	CA	90502	LOS ANGELES	USA	Lung Diseases Research	000	1	8/23/2025	NEW	$156,168
														Subtotal = $156,168

Grand Total All Awards = $156,168

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Exploring the role of Hedgehog pathway-Primary cilia axis in human lung alveologenesis and disease

Award Number: K99HL177341

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 08/01/2025

PERIOD OF PERFORMANCE END DATE: 07/31/2027

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