Thursday, September 18, 2025 9/18/2025

Elucidate the role of higher-order chromatin organization during terminal differentiation in mouse erythropoiesis

Award Number: K99DK140510
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 08/15/2025
PERIOD OF PERFORMANCE END DATE: 08/31/2027

Group Awards By:

View Award Description

Elucidate the role of higher-order chromatin organization during terminal differentiation in mouse erythropoiesis - Project Summary: It is widely appreciated that erythropoiesis serves as an excellent model for studying modifications in chromatin organization and resultant gene expression patterns within identical cells. This process involves significant chromatin reshuffling and a loss of topologically associating domains, ultimately leading to global transcriptional silencing upon terminal erythroid differentiation. Despite these insights, the precise structural changes underpinning the distinct gene expression seen in terminally differentiated erythroid cells remain enigmatic. Therefore, there is an urgent need to elucidate the detailed molecular mechanisms governing chromatin architecture modifications during erythroid terminal differentiation, to enhance our understanding of erythropoiesis-related diseases, particularly anemia. The overall objective of the proposed research is to decipher the roles and interactions of erythroid-specific transcription factors and chromatin structural proteins during erythropoiesis, defining how they lead from cellular expansion to differentiation. Our central hypothesis posits that erythroid-specific transcription factors and architectural proteins direct modifications in chromatin organization integral to erythroid terminal differentiation. To this end the specific aims of this proposal seek to combine functional studies with state-of-the-art-multi-omics approaches to: 1) Test the functional role of architectural proteins during terminal differentiation in mouse erythropoiesis 2) Identify and characterize chromatin re-organization events during terminal differentiation 3) Identifying the molecular mechanisms underlying the 3D chromatin changes during erythropoiesis


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $90,000 )
2025	2025	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	8/15/2025	NEW	$90,000
														Subtotal = $90,000

Grand Total All Awards = $90,000

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Elucidate the role of higher-order chromatin organization during terminal differentiation in mouse erythropoiesis

Award Number: K99DK140510

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 08/15/2025

PERIOD OF PERFORMANCE END DATE: 08/31/2027

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer