Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Partnering with Young Adults with Opioid Use Disorder to Co-Develop an Intervention Aimed at Reducing Substance-Related Harm and Enhancing Treatment Engagement

Award Number: K99DA065902
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 09/01/2026
PERIOD OF PERFORMANCE END DATE: 08/31/2028

Group Awards By:

View Award Description

Partnering with Young Adults with Opioid Use Disorder to Co-Develop an Intervention Aimed at Reducing Substance-Related Harm and Enhancing Treatment Engagement - PROJECT SUMMARY Young adults (YA; aged 18-25) are overdosing on opioids at alarming and increasing rates. Compared to adults older than 25, YA are more likely to experience a recent overdose, inject substances, and engage in risky drug use (e.g., sharing or re-using syringes). Unfortunately, available treatment options do not meet the distinct needs of YA. The vast majority who initiate treatment drop out prematurely, making them more likely to prematurely discontinue clinical care than any other age group. Only 15% continue with medication for opioid use disorder (MOUD)— the most proven lifesaving treatment for OUD associated with substantial reductions in morbidity and mortality risk— longer than six months. The first weeks after cessation of MOUD mark the period of highest overdose risk and death, further underscoring the significance of this problem. No intervention focused on reengaging these vulnerable youth in care or reducing the well-documented acute harms during this critical period exist. The purpose of this K99/R00 project is to address this significant gap in the clinical care pipeline by co-developing with YA a brief intervention, tailored to their unique developmental and clinical needs, to target mitigating acute overdose risks and reengaging YA in evidence-based care. Therefore, aims of the K99 phase are to recruit YA with OUD who prematurely terminated treatment, prescribers, and clinicians to participate in semi-structured focus groups and individual interviews in to assess system- and individual-level needs and barriers for YA SUD treatment (Aim 1a; n = 40); and to conduct a preliminary feasibility pilot study to test the acceptability and feasibility of the proposed intervention (Aim 1b; n = 5). The aims of the R00 phase are to conduct a 6-session randomized pilot trial (N = 68) to examine acceptability, feasibility, and satisfaction of brief intervention with YA with OUD who prematurely terminated treatment. The coordinated training plan will allow the applicant to leverage her expertise in community based participatory methods (CBPR), mixed- methods analysis, addiction science, and treatment approaches aimed at reducing substance-related harm, while also facilitating in-depth training in (1) working with young adults (YA) with OUD; (2) developing and designing substance use treatments; (3) conducting clinical trials and related methodology; and (4) professional development to prepare for independence. The applicant is supported by a highly skilled mentorship team (Drs. Miranda, Rich, Ramsey, and Magill) with collective expertise in the proposed training areas and a strong research environment. The proposed study aims to reduce substance-related harm and improve OUD treatment re-engagement and retention by developing a novel, developmentally tailored intervention co-developed with YA with OUD. Finishing this project would allow the PI to grow as an expert in substance use treatment approaches for YA and provide training in clinical trials. Data from this study would serve as pilot data for a large R01 RCT testing this intervention on a larger scale.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $160,092 )
2026	2026	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Drug Use and Addiction Research Programs	000	1	4/17/2026	NEW	$160,092
2026	2026	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Drug Use and Addiction Research Programs	001	1	4/30/2026	NEW	$0
														Subtotal = $160,092

Grand Total All Awards = $160,092

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Partnering with Young Adults with Opioid Use Disorder to Co-Develop an Intervention Aimed at Reducing Substance-Related Harm and Enhancing Treatment Engagement

Award Number: K99DA065902

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 09/01/2026

PERIOD OF PERFORMANCE END DATE: 08/31/2028

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer