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Developing a framework to individualize surgical decision-making for older adults with primary hyperparathyroidism: Administrative supplement to promote research continuity and retention

Award Number: K76AG068526
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Developing a framework to individualize surgical decision-making for older adults with primary hyperparathyroidism: Administrative supplement to promote research continuity and retention - PROJECT SUMMARY/ABSTRACT This is an Administrative Supplement for a parent Beeson K76 Career Development award that will address the unmet need for patient-specific decision support tools for surgical interventions in older adults and provide a platform for Dr. Carolyn Seib to become a leader in geriatric surgery. Primary hyperparathyroidism (PHPT) is a common endocrine disorder in older adults that is associated with serious long-term morbidity, including osteoporotic fractures, kidney stones, and chronic kidney disease (CKD). Parathyroidectomy can prevent these morbid sequelae. However, increased surgical risk associated with advanced age and frailty, in addition to the competing risk of death prior to achieving benefit from surgical intervention, raises the question of whether the risks of parathyroidectomy outweigh long-term risk reduction in this group. Identifying older adults likely to benefit from surgical interventions, such as parathyroidectomy, while preventing overuse in this vulnerable group, is critical to improve patient-centered care. There is no standardized methodology for developing surgical decision support for older adults that incorporates individualized risk prediction and stakeholder input to facilitate patient-centered decision-making. Therefore, this coordinated research and training proposal aims to: 1) compare the effects of parathyroidectomy vs. medical management on the incidence of fractures, kidney stones, and CKD in older adults with PHPT; 2) develop and validate predictive models for the perioperative risks of parathyroidectomy and long-term risks of fractures, kidney stones, and CKD specific to older adults with PHPT; and 3) design and test with stakeholder feedback a PHPT decision support tool that describes the tradeoffs of parathyroidectomy vs. non-operative management. To accomplish these aims, Dr. Seib will obtain training in comparative effectiveness and predictive modeling, qualitative and mixed methods research, and implementation science, which will support Dr. Seib’s transition to research independence. Upon completion of this research, Dr. Seib will have a user-tested risk/benefit calculator that will form the basis of a decision support tool to improve patient-centered treatment recommendations for older adults with PHPT. In addition, this research will establish a framework for developing patient-centered decision support that can be applied to other conditions to promote appropriate surgical management of older adults. This proposal is significant because it directly addresses the gap in decision support tools for PHPT and other surgically managed conditions in older adults. This project is innovative because it proposes a paradigm shift to incorporate geriatric principles to individualize treatment decisions in older adults with PHPT to optimize clinical outcomes. At the end of the proposed research, Dr. Seib will have the data and skills necessary to successfully pursue R01 funding for a hybrid type 1 effectiveness-implementation trial to test this decision support tool and apply this methodology to other conditions with surgical treatment options that affect older adults.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $318,600 )
2024	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Aging Research	003	3	7/12/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Aging Research	002	3	6/5/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Aging Research	001	4	5/30/2024	NON-COMPETING CONTINUATION	$243,000
2024	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Aging Research	000	3	11/22/2023	SUPPLEMENT FOR EXPANSION	$75,600
														Subtotal = $318,600

Issue Date FY: 2023 ( Subtotal = $243,000 )
2023	2023	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Aging Research	000	3	5/24/2023	NON-COMPETING CONTINUATION	$243,000
														Subtotal = $243,000

Issue Date FY: 2022 ( Subtotal = $243,000 )
2022	2022	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Aging Research	000	2	7/7/2022	NON-COMPETING CONTINUATION	$243,000
														Subtotal = $243,000

Issue Date FY: 2021 ( Subtotal = $243,000 )
2021	2021	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Aging Research	000	1	9/23/2021	NEW	$243,000
														Subtotal = $243,000

Grand Total All Awards = $1,047,600

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Developing a framework to individualize surgical decision-making for older adults with primary hyperparathyroidism: Administrative supplement to promote research continuity and retention

Award Number: K76AG068526

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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