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Development and Application of T1rho Dispersion Imaging of Aging Muscle

Award Number: K25AG076864
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 06/01/2022
PERIOD OF PERFORMANCE END DATE: 05/31/2026

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Development and Application of T1rho Dispersion Imaging of Aging Muscle - Project Summary This administrative supplement is requested to support research continuity and retention of the scientific aims outlined in a K25 NIAAward #1K25AG076864, titled Development and Application of T1rho Dispersion Imaging of Aging Muscle. The principal investigator is currently managing a high-risk pregnancy and childbirth-related life events that may temporarily affect her research productivity and the success of her K25 grant. The aims of the parent grant are (1) to develop R1p (R1p = 1/T1p - the spin-lattice relaxation rates in the rotating frame) dispersion imaging at weak locking field frequency, a novel approach that can quantify degenerative changes in microvasculature and abnormal macromolecule accumulation in muscle fiber membranes, (2) to validate extracted-MRI indices using gold-standard ex vivo methods through a longitudinal study of skeletal muscle in F344 rats to establish the pathophysiological relevance of these novel MRI biomarkers with aging, and (3) to translate R1p dispersion imaging to human research, utilizing a clinical 3T MRI scanner to assess skeletal muscle changes with healthy aging. The parent grant has enabled successful completion of Aim 1 and Aim 2, and partial progress toward Aim 3. To fully accomplish the objectives outlined in Aim 2, additional computational analysis of histological data is necessary. To support this activity, I have established a collaboration with experts at the Digital Histology Shared Resource (DHSR), in partnership with the Translational Pathology Shared Resource (TPSR) at Vanderbilt University Medical Center. This collaboration will enable cost-effective computational quantification of ex vivo biomarkers, which are essential for interpreting MRI-derived indices from Aim 2. This supplement is also vital for advancing Aim 3 by ensuring continuity of human research activities during a temporary reduction in the principal investigator's availability and productivity. A research assistant (RA) will be hired through this administrative supplement to support subject recruitment, scheduling volunteer visits, and conducting clinical assessments. The RA has received or will receive appropriate training to perform basic clinical evaluation and analyze demographic data, helping to maintain momentum in the human imaging component of the study. Overall, this support is crucial for maintaining the integrity and progress of the parent grant during a period of limited Pl availability.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $75,600 )
2026	2026	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Aging Research	000	4	1/15/2026	SUPPLEMENT FOR EXPANSION	$75,600
														Subtotal = $75,600

Issue Date FY: 2025 ( Subtotal = $119,474 )
2025	2025	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Aging Research	000	4	6/3/2025	NON-COMPETING CONTINUATION	$119,474
														Subtotal = $119,474

Issue Date FY: 2024 ( Subtotal = $119,474 )
2024	2024	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Aging Research	000	3	6/28/2024	NON-COMPETING CONTINUATION	$119,474
														Subtotal = $119,474

Issue Date FY: 2023 ( Subtotal = $195,334 )
2023	2023	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Aging Research	000	1	3/29/2023	SUPPLEMENT FOR EXPANSION	$75,860
2023	2023	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Aging Research	001	2	4/28/2023	NON-COMPETING CONTINUATION	$119,474
														Subtotal = $195,334

Issue Date FY: 2022 ( Subtotal = $119,474 )
2022	2022	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Aging Research	000	1	5/26/2022	NEW	$119,474
														Subtotal = $119,474

Grand Total All Awards = $629,356

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Development and Application of T1rho Dispersion Imaging of Aging Muscle

Award Number: K25AG076864

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 06/01/2022

PERIOD OF PERFORMANCE END DATE: 05/31/2026

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