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Investigations of Pathologic Remodeling Using Pediatric Heart Failure Serum

Award Number: K24HL150630
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 12/01/2019
PERIOD OF PERFORMANCE END DATE: 11/30/2024

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Investigations of Pathologic Remodeling Using Pediatric Heart Failure Serum - Abstract Heart failure (HF) is one of the leading causes of hospitalization in the United States and is associated with substantial adverse effects on quality of life as well as a mortality rate on the order of the most lethal forms of cancer. Treatment for adults with HF varies from well- established neurohormonal inhibitors to device therapy. However, despite the demonstrated benefits of current therapy, the societal and economic burdens of HF are increasing. In pediatric HF from dilated cardiomyopathy (DCM) five-year freedom from death or transplant remains low, ranging from 54%-63%. This suggests that there are underlying myocardial cellular mechanisms uniquely regulated in children with HF. Irrespective of age or etiology of HF, new therapies for HF are necessary to improve morbidity and mortality and decrease health care costs. The proposed studies will use meticulously preserved pediatric serum along with all relevant clinical data, and are designed to integrate patient samples with an in vitro system that is a surrogate for pathological changes observed in the myocardium. In addition, this award will provide protected time for Dr. Sucharov to continue her successful mentorship of junior faculty and fellows trainees. The translational aspect of this work will be relevant to MD fellows and junior faculty, and will allow patient oriented research without risk to children with HF.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $106,046 )
2024	2024	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Cardiovascular Diseases Research	000	5	11/9/2023	NON-COMPETING CONTINUATION	$106,046
														Subtotal = $106,046

Issue Date FY: 2023 ( Subtotal = $106,674 )
2023	2023	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Cardiovascular Diseases Research	000	4	12/1/2022	NON-COMPETING CONTINUATION	$106,674
														Subtotal = $106,674

Issue Date FY: 2022 ( Subtotal = $107,361 )
2022	2022	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Cardiovascular Diseases Research	000	3	1/7/2022	NON-COMPETING CONTINUATION	$107,361
														Subtotal = $107,361

Issue Date FY: 2021 ( Subtotal = $108,028 )
2021	2021	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Cardiovascular Diseases Research	000	2	12/7/2020	NON-COMPETING CONTINUATION	$108,028
														Subtotal = $108,028

Issue Date FY: 2020 ( Subtotal = $108,676 )
2020	2020	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Cardiovascular Diseases Research	000	1	11/29/2019	NEW	$108,676
														Subtotal = $108,676

Grand Total All Awards = $536,785

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Investigations of Pathologic Remodeling Using Pediatric Heart Failure Serum

Award Number: K24HL150630

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 12/01/2019

PERIOD OF PERFORMANCE END DATE: 11/30/2024

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