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The Next Generation of Innovative Cardiovascular Clinical/Translational Researchers

Award Number: K24HL145076
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 01/01/2019
PERIOD OF PERFORMANCE END DATE: 12/31/2023

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The Next Generation of Innovative Cardiovascular Clinical/Translational Researchers - Project Summary/Abstract My career focus is research and educational efforts to reduce early cardiovascular disease (CVD) risk factors. Obesity, diabetes, and underlying insulin resistance (IR) are major contributors to CVD, accelerated by the current pediatric obesity epidemic. Unique factors in youth with type 2 diabetes (T2D) lead to early insulin dependence and progression of co-morbidities that accelerate CVD and mortality, and typical adult T2D treatments are ineffective in youth. The mechanism of IR in T1D is also unclear, limiting our ability to reduce CVD risk in T1D. Moreover, current CV-assessment tools are often too invasive for youth. My prior research training, initial leadership experiences and collaborations with cardiology, bioengineering, and radiology provide the skills and combined expertise to address these critical voids. An NHLBI K24 grant will train me to better provide mentorship in high-impact POR to CVD-focused physician-scientists of exceptional potential and nurture a diverse pipeline of new investigators. My career goals are to: 1) Better understand early precursors of CVD in the underserved population of youth with obesity/diabetes 2) Develop non-invasive approaches to CVD risk-assessment tolerable to youth 3) Develop new medical and/or surgical treatments to reduce CVD risk in youth and 4) Learn how to best engage, motivate and train a diverse set of emerging researchers in cutting- edge POR. Support as a K24 scholar will provide dedicated time to benefit from the exceptional POR mentoring and leadership training resources of our campus and beyond, and focus on these goals. My K24 application includes an overview of: 1) My skills, record and dedication to mentoring in POR; 2) A strategy to reduce administrative/clinical obligations and focus on mentoring; 3) An impactful, cutting-edge K24 POR proposal with numerous opportunities for trainees; 4) A strategy for integrating expert collaborators as a K24 Advisory Committee to deliver superior and cohesive training, mentoring and oversight of junior colleagues and to assure a pipeline of future trainees; 5) Evidence of a robust pool of protected early career POR investigators to benefit from K24 support; 6) A timeline for training in responsible conduct of research; 7) Evidence of the collaborator, institutional and environmental support underlying my POR program and for the K24 proposal. My Aims as an NHLBI K24 Scholar are to: 1) Strengthen mentoring of a diverse set of early career investigators to create a pipeline of well-trained physician-scientists focused on CVD POR. Rationale: The proposed training plan offers exceptional support, environment and expertise for creating a POR career in CVD prevention. I will integrate my current mentoring skills with those gained from the K24, to deliver the highest quality mentorship. 2). Build upon my CVD risk-reduction POR in youth-onset obesity/diabetes. Rationale: Given K24 support, I am positioned to enhance the quality and breadth of our POR research, and thereby improve the lives of the growing numbers of youth with obesity and diabetes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$3,790 )
2024	2023	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Cardiovascular Diseases Research	000	5	5/10/2024	NON-COMPETING CONTINUATION	-$3,790
														Subtotal = -$3,790

Issue Date FY: 2023 ( Subtotal = $114,891 )
2023	2023	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Cardiovascular Diseases Research	000	5	12/12/2022	NON-COMPETING CONTINUATION	$114,891
														Subtotal = $114,891

Issue Date FY: 2022 ( Subtotal = $114,891 )
2022	2022	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Cardiovascular Diseases Research	000	4	1/7/2022	NON-COMPETING CONTINUATION	$114,891
														Subtotal = $114,891

Issue Date FY: 2021 ( Subtotal = $114,891 )
2021	2021	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Cardiovascular Diseases Research	000	3	1/11/2021	NON-COMPETING CONTINUATION	$114,891
														Subtotal = $114,891

Issue Date FY: 2020 ( Subtotal = $114,891 )
2020	2020	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Cardiovascular Diseases Research	000	2	1/21/2020	NON-COMPETING CONTINUATION	$114,891
														Subtotal = $114,891

Issue Date FY: 2019 ( Subtotal = $114,891 )
2019	2019	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Cardiovascular Diseases Research	000	1	12/26/2018	NEW	$114,891
														Subtotal = $114,891

Grand Total All Awards = $570,665

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The Next Generation of Innovative Cardiovascular Clinical/Translational Researchers

Award Number: K24HL145076

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 01/01/2019

PERIOD OF PERFORMANCE END DATE: 12/31/2023

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