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ALDOSTERONE IN VASCULAR REMODELING AND DYSFUNCTION

Award Number: K24HL004334
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 04/01/2000
PERIOD OF PERFORMANCE END DATE: 12/31/2008

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ALDOSTERONE IN VASCULAR REMODELING AND DYSFUNCTION - DESCRIPTION (provided by applicant): This is a competing continuation of a K 24 award from the candidate who is an Associate Professor of Medicine at Boston University School of Medicine (BUSM), and a senior clinical investigator at the Framingham Heart Study (FHS). His training in cardiology and epidemiology, mentoring and program development skills, and excellent track record in conducting and mentoring clinical research render him a suitable candidate for this research career award. During the award period, the candidate will continue to spend 40% effort on the research outlined below (including mentoring), 45% effort on his other research support, and 15% on clinical work. His long-term career objectives are to work as a clinical investigator building on the research theme of investigating biomarkers of preclinical heart failure, genetic and environmental correlates of ventricular remodeling, epidemiology of vascular dysfunction (endothelial dysfunction and conduit artery stiffness) and abnormal ventriculo-vascular coupling (and relations to heart failure risk), and to mentor young clinical investigators. The interdisciplinary research group, the high-quality research infrastructure, the opportunities for mentoring, and the support of senior colleagues render the FHS and BUSM ideal settings for the candidate's pursuit of his career as a clinical investigator. The current proposal investigates the role of aldosterone in mediating vascular dysfunction and has the following specific aims: 1. To assess the clinical, inflammatory and genetic correlates of serum aldosterone. 2. To perform cross-sectional analyses on the relations of serum aldosterone to carotid intimal medial thickness, and to dynamic measures of central conduit artery function. 3. To perform cross-sectional analyses on the relations of serum aldosterone to select measures of brachial arterial endothelial function; and to microalbuminuria. 4. To describe the relations of serum aldosterone prospectively to incident CVD events The proposed K 24 award will allow the candidate and his mentees to focus on the vascular biology of aldosterone and its relations to vascular dysfunction and risk over the next five years, and will provide the candidate an opportunity for nurturing the next generation of patient-oriented researchers. The mentorship plan consists of mentoring the research of and teaching a module on clinical research design to fellows at the FHS and BUSM and will contribute directly to the growth and development of young clinical investigators at these institutions. Activities for career development of the candidate are also planned in the areas of proteomics and genetic epidemiology.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2008 ( Subtotal = $97,456 )
2008	2008	BOSTON UNIVERSITY	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Cardiovascular Diseases Research	000	8	2/7/2008	NON-COMPETING CONTINUATION	$97,456
														Subtotal = $97,456

Issue Date FY: 2007 ( Subtotal = $95,404 )
2007	2007	BOSTON UNIVERSITY	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Cardiovascular Diseases Research	000	7	12/5/2006	NON-COMPETING CONTINUATION	$95,404
														Subtotal = $95,404

Issue Date FY: 2006 ( Subtotal = $93,411 )
2006	2006	BOSTON UNIVERSITY	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Cardiovascular Diseases Research	000	6	12/29/2005	NON-COMPETING CONTINUATION	$93,411
														Subtotal = $93,411

Issue Date FY: 2005 ( Subtotal = $91,477 )
2005	2005	BOSTON UNIVERSITY	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Cardiovascular Diseases Research	000	5	1/10/2005	NON-COMPETING CONTINUATION	$91,477
														Subtotal = $91,477

Issue Date FY: 2004 ( Subtotal = $89,599 )
2004	2004	BOSTON UNIVERSITY	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Cardiovascular Diseases Research	000	4	2/16/2004	COMPETING CONTINUATION	$89,599
														Subtotal = $89,599

Issue Date FY: 2003 ( Subtotal = $81,454 )
2003	2003	BOSTON UNIVERSITY	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Cardiovascular Diseases Research	000	3		NON-COMPETING CONTINUATION	$81,454
														Subtotal = $81,454

Issue Date FY: 2002 ( Subtotal = $79,867 )
2002	2002	BOSTON UNIVERSITY	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Cardiovascular Diseases Research	000	2	12/20/2001	NON-COMPETING CONTINUATION	$79,867
														Subtotal = $79,867

Issue Date FY: 2001 ( Subtotal = $78,328 )
2001	2001	BOSTON UNIVERSITY	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Cardiovascular Diseases Research	000	1	7/2/2001	NEW	$78,328
														Subtotal = $78,328

Grand Total All Awards = $706,996

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ALDOSTERONE IN VASCULAR REMODELING AND DYSFUNCTION

Award Number: K24HL004334

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 04/01/2000

PERIOD OF PERFORMANCE END DATE: 12/31/2008

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