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Training program in the neurology of language and neurodegenerative aphasias

Award Number: K24DC015544
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/01/2016
PERIOD OF PERFORMANCE END DATE: 06/30/2026

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Training program in the neurology of language and neurodegenerative aphasias - This K24 grant renewal is requested to support the mentoring activities of Dr. Maria Luisa Gorno Tempini, a behavioral neurologist and cognitive neuroscientist. Dr. Gorno Tempini is a leading researcher and clinician in the fields of neurology and the neuroscience of language, with specific expertise in atypical neurodegenerative diseases that present as speech and language disorders. She mentors a talented group of clinicians and researchers to study and treat Primary Progressive Aphasia (PPA) and investigate the neural basis of language. Dr. Gorno Tempini has a proven track record of success in mentoring both clinicians and scientists in patient- oriented research (POR) related to speech and language disorders. The goals of this proposal are to support time for Dr. Gorno Tempini to mentor a growing number of increasingly diverse clinicians and researchers interested in neurodegenerative language disorders, to extend her impact as a mentor at UCSF, and to pursue novel lines of research in PPA. Leveraging the resources available at the UCSF Memory and Aging Center (MAC), the Global Brain Health Institute, and the UCSF Clinical and Translational Science Institute, she will mentor clinicians, faculty, postdoctoral scholars, and scientists with particular attention to cultivating diversity, equity, and inclusion in her laboratory, the university, and the profession at large. She will sustain her comprehensive mentoring system that features one-on-one mentoring, supervision of clinicians in patient diagnosis and care, and group mentoring activities. She will update and extend that system with opportunities for training with colleagues in speech and data science and a focus on mentoring more advanced junior colleagues as emerging mentors themselves. Dr. Gorno Tempini's experience in basic cognitive neuroscience and neurological methodologies and her increasingly nuanced leadership expertise uniquely position her to benefit a diverse group of trainees. The research project proposed here will develop automatic, efficient, and objective methods to measure speech production in PPA. The study will apply acoustic analysis scripts and automatic speech recognition to five minutes of audio recordings collected from 500 well-characterized PPA patients and employ dynamic speech MRI to identify anatomical biomarkers of vocal tract movements corresponding to speech articulation errors. This will lead to earlier detection of speech deficits; improved characterization of clinical syndromes; and more detailed, objective, and efficient outcome measures to track progression and, in the future, response to treatment. Machine learning analyses of acoustic measures and imaging data collected through other MAC projects will provide novel tools for prediction of post-mortem pathology and new knowledge on the neural basis of speech. This grant will be instrumental in supporting the pursuit of Dr. Gorno Tempini's goals to mentor the next generation of clinician scientists in the neurology of language and neurodegenerative aphasias.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2027 ( Subtotal = -$461 )
2027	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Research Related to Deafness and Communication Disorders	000	10	10/14/2026	NON-COMPETING CONTINUATION	-$461
														Subtotal = -$461

Issue Date FY: 2025 ( Subtotal = $188,829 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Research Related to Deafness and Communication Disorders	000	10	6/26/2025	NON-COMPETING CONTINUATION	$188,829
														Subtotal = $188,829

Issue Date FY: 2024 ( Subtotal = $188,829 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Research Related to Deafness and Communication Disorders	000	9	6/8/2024	NON-COMPETING CONTINUATION	$188,829
														Subtotal = $188,829

Issue Date FY: 2023 ( Subtotal = $188,829 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Research Related to Deafness and Communication Disorders	001	8	7/20/2023	NON-COMPETING CONTINUATION	$188,829
2023	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Research Related to Deafness and Communication Disorders	000	7	10/19/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $188,829

Issue Date FY: 2022 ( Subtotal = $188,829 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Research Related to Deafness and Communication Disorders	004	7	8/5/2022	NON-COMPETING CONTINUATION	$188,829
2022	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Research Related to Deafness and Communication Disorders	002	6	1/10/2022	COMPETING CONTINUATION	-$150,719
2022	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Research Related to Deafness and Communication Disorders	003	6	1/10/2022	COMPETING CONTINUATION	$150,719
2022	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Research Related to Deafness and Communication Disorders	001	6	12/10/2021	COMPETING CONTINUATION	$150,719
2022	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Research Related to Deafness and Communication Disorders	000	5	12/7/2021	NON-COMPETING CONTINUATION	-$150,719
														Subtotal = $188,829

Issue Date FY: 2021 ( Subtotal = $188,829 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Research Related to Deafness and Communication Disorders	000	6	7/11/2021	COMPETING CONTINUATION	$188,829
														Subtotal = $188,829

Issue Date FY: 2020 ( Subtotal = $186,537 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Research Related to Deafness and Communication Disorders	000	5	6/26/2020	NON-COMPETING CONTINUATION	$186,537
														Subtotal = $186,537

Issue Date FY: 2019 ( Subtotal = $186,537 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Research Related to Deafness and Communication Disorders	000	4	6/24/2019	NON-COMPETING CONTINUATION	$186,537
														Subtotal = $186,537

Issue Date FY: 2018 ( Subtotal = $186,537 )
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 420	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Research Related to Deafness and Communication Disorders	000	3	6/12/2018	NON-COMPETING CONTINUATION	$186,537
														Subtotal = $186,537

Issue Date FY: 2017 ( Subtotal = $186,537 )
2017	2017	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Research Related to Deafness and Communication Disorders	000	2	6/14/2017	NON-COMPETING CONTINUATION	$186,537
														Subtotal = $186,537

Issue Date FY: 2016 ( Subtotal = $186,537 )
2016	2016	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Research Related to Deafness and Communication Disorders	000	1	6/30/2016	NEW	$186,537
														Subtotal = $186,537

Grand Total All Awards = $1,876,369

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Training program in the neurology of language and neurodegenerative aphasias

Award Number: K24DC015544

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/01/2016

PERIOD OF PERFORMANCE END DATE: 06/30/2026

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