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EnhAncing Research and meNtoring Skills in Tuberculosis (EARN TB)

Award Number: K24AI190403
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 08/04/2025
PERIOD OF PERFORMANCE END DATE: 07/31/2030

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EnhAncing Research and meNtoring Skills in Tuberculosis (EARN TB) - PROJECT SUMMARY Despite the advent of new diagnostics and treatments, tuberculosis (TB) remains a public health burden in the U.S. and a leading cause of mortality worldwide. There is an urgent need to better understand the host immune response to Mycobacterium tuberculosis (Mtb) and its role in causing lung damage and lung health morbidity as well as to train the next generation of TB scientists in the U.S. focused on patient-oriented research. The overarching goal of this K24 is to provide support for Dr. Russell Kempker to 1) have the protected time needed to successfully mentor early-stage investigators in TB patient oriented research, 2) receive training in host immunology and bioinformatics as well as in team science, mentorship, and leadership and 3) to carry out innovative TB translational research on the host immune response to Mtb. Dr. Kempker has mentored >40 U.S. trainees in TB patient oriented research and has leadership positions in numerous TB research capacity building programs including serving as the Co-Director of the NIH NIAID supported Emory/Georgia TB Research Advancement Center (TRAC) Developmental Core and MPI and Associate Program Director of two Fogarty International Center D43 Global Infectious Diseases TB Research Training Programs. The proposed research will leverage an ongoing NIAID R01 study (Contact PI, Kempker; R01AI173946) to conduct the proposed research and to provide mentored research opportunities for U.S. early-career investigators. This K24 would utilize a unique cohort of persons with pulmonary TB undergoing adjunctive surgical resection to support new studies including 1) evaluating the impact of surgical removal of Mtb diseased lung on decreasing systemic inflammation and 2) utilizing enhanced spatial transcriptomics methods to evaluate the host immune response associated with various types of lung granulomas at a single cell level. Findings from this newly proposed research are expected to provide critical insights that can inform strategies for developing novel host directed therapies that could limit post TB lung disease which is a growing problem in the U.S. Emory University provides an excellent environment for achieving the training goals for this K24 proposal and through its various schools and partners for the recruitment of a diverse, strong pool of early stage investigators. Overall, this proposal would directly address key research priorities in the NIAID TB strategic research agenda and provide Dr. Kempker the time and skills to effectively mentoring the next generation of impactful biomedical scientists in patient oriented clinical and translational research thereby developing a cadre of investigators capable of combatting TB and hence enhancing U.S. public health preparedness. The long-term goal of the proposed activities in this K24 proposal are focused on improving the lives of persons inflicted and suffering from TB and to help in the fight to end TB.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $192,027 )
2026	2026	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	2	8/4/2026	NON-COMPETING CONTINUATION	$192,027
														Subtotal = $192,027

Issue Date FY: 2025 ( Subtotal = $192,027 )
2025	2025	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	1	8/4/2025	NEW	$192,027
														Subtotal = $192,027

Grand Total All Awards = $384,054

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EnhAncing Research and meNtoring Skills in Tuberculosis (EARN TB)

Award Number: K24AI190403

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 08/04/2025

PERIOD OF PERFORMANCE END DATE: 07/31/2030

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