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Mentoring translational scientists in international infectious disease research

Award Number: K24AI144048
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 01/22/2019
PERIOD OF PERFORMANCE END DATE: 12/31/2028

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Mentoring translational scientists in international infectious disease research - Abstract Dr. Greenhouse is a physician scientist trained in internal medicine, infectious diseases, and biostatistics. Over the past 18 years, he has worked across domains of field epidemiology, laboratory science, data science, and public health to investigate the epidemiology of infectious diseases, with a focus on disease transmission and development of immunity. His growth as a scientist and mentor was substantially accelerated due to the dedicated time afforded by his current K24. Studies to accomplish the research aims outlined in his prior K24 application have all been published as peer-reviewed papers and/or are the subject of active, R01- level NIH grants where he or a clinician scientist that he mentors serves as principal investigator. During this project period he published 80 papers, was PI on 3 new grants including R01 and U01 awards from NIAID, was co-investigator on 6 new grants, and was primary mentor for 2 new K awards. Regarding mentorship, he supervised 39 trainees including 14 from low- or middle-income countries, cofounded the UCSF EPPIcenter as a center of excellence for research and training in patient-oriented research, created two longitudinal training programs in malaria genetic epidemiology for African scientists, and co-led 3 workshops in genomic epidemiologic analysis for over 100 African scientists. During the next K24 project period, Dr. Greenhouse proposes to 1) focus on leadership development so he can better guide the growth and success of the EPPIcenter; 2) expand the scope of his research portfolio to include pathogens beyond malaria and the addition of domestic research; and 3) establish an interactive, online training platform in genomic epidemiologic analysis. He presents a plan for achieving these goals by obtaining leadership development training, expanding his skill set in the epidemiology of respiratory viruses and laboratory methods for multi-pathogen surveillance, and developing expertise in curricular development and other principles such as the use of technology for effective teaching. Dr. Greenhouse’s existing research portfolio provides a wealth of opportunities for trainees, including projects studying the longitudinal development of naturally acquired immunity to malaria using birth cohorts to simultaneously study the pathogen and the host; systems immunology and computational analysis to comprehensively characterize factors associated with development of immunity to malaria; and an array of projects related to the genomic epidemiology of malaria including multiple with explicit training and capacity building goals. He proposes to expand the scope of his research portfolio with 3 specific aims: 1) to develop and apply amplicon sequencing tools to solve current challenges in malaria surveillance; 2) to characterize the pathogen landscape of non- malarial febrile illness in Uganda; and 3) to characterize the transmission of respiratory pathogens in an urban immigrant community in San Francisco.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $197,626 )
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	8	12/17/2025	NON-COMPETING CONTINUATION	$197,626
														Subtotal = $197,626

Issue Date FY: 2025 ( Subtotal = $197,626 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	7	12/18/2024	NON-COMPETING CONTINUATION	$197,626
2025	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	002	6	1/19/2025	COMPETING CONTINUATION	$12,979
2025	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	001	5	1/19/2025	NON-COMPETING CONTINUATION	-$12,979
														Subtotal = $197,626

Issue Date FY: 2024 ( Subtotal = $197,226 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	6	12/26/2023	COMPETING CONTINUATION	$197,226
														Subtotal = $197,226

Issue Date FY: 2023 ( Subtotal = $191,553 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	5	12/16/2022	NON-COMPETING CONTINUATION	$191,553
														Subtotal = $191,553

Issue Date FY: 2022 ( Subtotal = $191,553 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	4	12/3/2021	NON-COMPETING CONTINUATION	$191,553
														Subtotal = $191,553

Issue Date FY: 2021 ( Subtotal = $191,553 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	3	12/17/2020	NON-COMPETING CONTINUATION	$191,553
														Subtotal = $191,553

Issue Date FY: 2020 ( Subtotal = $191,553 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	2	12/16/2019	NON-COMPETING CONTINUATION	$191,553
														Subtotal = $191,553

Issue Date FY: 2019 ( Subtotal = $191,553 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	1	1/22/2019	NEW	$191,553
														Subtotal = $191,553

Grand Total All Awards = $1,550,243

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Mentoring translational scientists in international infectious disease research

Award Number: K24AI144048

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 01/22/2019

PERIOD OF PERFORMANCE END DATE: 12/31/2028

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