Monday, February 16, 2026 2/16/2026

Neuropathological changes underlying clinical heterogeneity in Alzheimer dise

Award Number: K24AG053435
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 08/15/2016
PERIOD OF PERFORMANCE END DATE: 03/31/2026

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Neuropathological changes underlying clinical heterogeneity in Alzheimer dise - Project Summary This is an application for K24 award renewal for Dr. Lea T. Grinberg, a neuropathologist at the University of California, San Francisco (UCSF). Dr. Grinberg is an Associate Professor in Residence and co-lead the UCSF/Memory and Aging Center's Neuropathology Core. She is an established researcher in the patient- oriented clinical research of dementia. A distinctive hallmark of her research is her direct involvement in creating, managing, and analyzing well-characterized postmortem collections of brains belonging to people at-risk or already with dementia. Dr. Grinberg proposes to use K24 dedicated time to mentor USCF as well as international investigators in patient-oriented dementia research. Her mentees will gain hands-on research experience, expertise in age-related human neuropathology, training in data analysis, manuscript preparation, and grant writing, as well as career, mentoring. Mentee training will leverage the infrastructure and resources of the UCSF/Memory and Aging Center Autopsy program, which is part of ongoing longitudinal cohort studies, research portfolio, and her collaborations with multidisciplinary researchers in the areas of dementia domestically and worldwide. Dr. Grinberg intends to conduct K24-supported Alzheimer's disease research studies that will serve as training vehicles for mentees and expand her research. These studies, using clinical, genetic, and neuropathological data, will be conducted using data from ongoing UCSF/Memory and Aging Center's NIH- funded cohort studies of persons with Alzheimer's disease (AD). She will examine the factors underlying selective neuronal vulnerability in AD. In summary, this K24 will enhance Dr. Ginberg's active research program with extensive infrastructure at UCSF to support her goal to remain a leader in neurodegenerative diseases, especially in the field of neuropathology, and to develop a program of excellence for training medical students, trainees, and junior faculty in POR related to age-related neuropathology that is also intended to close the gaps caused by interruption of neuropathology training for neurologists and neurodegenerative disease training for neuropathologists.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	MAYO CLINIC JACKSONVILLE (A NONPROFIT CORPORATION)	4500 SAN PABLO RD S	JACKSONVILLE	FL	32224	DUVAL	USA	Aging Research	001	11	2/12/2026	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$140,341
2026	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	000	10	2/11/2026	NON-COMPETING CONTINUATION	-$140,341
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $188,296 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	000	10	5/20/2025	NON-COMPETING CONTINUATION	$188,296
														Subtotal = $188,296

Issue Date FY: 2024 ( Subtotal = $188,296 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	000	9	6/7/2024	NON-COMPETING CONTINUATION	$188,296
														Subtotal = $188,296

Issue Date FY: 2023 ( Subtotal = $188,296 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	000	8	3/20/2023	NON-COMPETING CONTINUATION	$188,296
														Subtotal = $188,296

Issue Date FY: 2022 ( Subtotal = $188,296 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	001	7	5/31/2022	NON-COMPETING CONTINUATION	$188,296
2022	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	000	5	4/25/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $188,296

Issue Date FY: 2021 ( Subtotal = $188,296 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	000	6	7/9/2021	COMPETING CONTINUATION	$188,296
2021	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	001	5	9/1/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $188,296

Issue Date FY: 2020 ( Subtotal = $164,900 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	000	5	5/14/2020	NON-COMPETING CONTINUATION	$164,900
														Subtotal = $164,900

Issue Date FY: 2019 ( Subtotal = $164,900 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	000	4	6/4/2019	NON-COMPETING CONTINUATION	$164,900
														Subtotal = $164,900

Issue Date FY: 2018 ( Subtotal = $164,900 )
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 420	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	000	3	6/27/2018	NON-COMPETING CONTINUATION	$164,900
														Subtotal = $164,900

Issue Date FY: 2017 ( Subtotal = $164,900 )
2017	2017	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	000	2	5/16/2017	NON-COMPETING CONTINUATION	$164,900
														Subtotal = $164,900

Issue Date FY: 2016 ( Subtotal = $164,900 )
2016	2016	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	001	1	8/24/2016	NEW	$0
2016	2016	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	000	1	8/11/2016	NEW	$164,900
														Subtotal = $164,900

Grand Total All Awards = $1,765,980

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Neuropathological changes underlying clinical heterogeneity in Alzheimer dise

Award Number: K24AG053435

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 08/15/2016

PERIOD OF PERFORMANCE END DATE: 03/31/2026

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