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Risk factors and prevention targets for abnormal cognitive aging

Award Number: K24AG046373
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 01/01/2019
PERIOD OF PERFORMANCE END DATE: 12/31/2024

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Risk factors and prevention targets for abnormal cognitive aging - This proposal is requesting a one-time renewal of a Midcareer Investigator Award in Patient-Oriented Research (K24). The candidate, Dr. Angela Jefferson, is a neuropsychologist whose interdisciplinary research program focuses on understanding the impact of cardiovascular and cerebrovascular integrity on the pathogenesis and clinical manifestation of Alzheimer's disease and small vessel disease. Dr. Jefferson is a Professor of Neurology at Vanderbilt University Medical Center and founding Director of the Vanderbilt Memory & Alzheimer's Center. Since completing her training 13 years ago, Dr. Jefferson has established herself as a productive clinical researcher with strong NIH funding and a high-impact, prolific publication record. Over the last decade, including the original K24 funding period (2013-2018), she has demonstrated a strong commitment to professional education and mentorship. This K24 renewal will be instrumental in continuing to provide protected time for Dr. Jefferson to expand her clinical research capabilities. In particular, she will expand her expertise in cerebrospinal fluid biomarkers of Alzheimer's disease to include innovative molecular biomarkers reflecting concomitant pathways, such as extracellular matrix remodeling, microglial activation, and synaptic dysfunction. She will also expand the breadth of proteomic biomarkers at her disposal by leveraging state of the art discovery-based mass spectrometry methods. These tools will substantially enrich our understanding of the mechanisms by which compromised vascular health relates to abnormal brain aging and inform strategies to prevent or delay the pathological cascade associated with cognitive impairment and dementia. Furthermore, the proposed award will allow Dr. Jefferson to continue to use her research program as a platform to mentor early career investigators, including undergraduate, graduate, and medical students; postdoctoral fellows; and early career faculty in patient-oriented research in cognitive aging, Alzheimer's disease, and small vessel disease. This proposal integrates Dr. Jefferson's interdisciplinary research team and resources available through the Vanderbilt Memory & Alzheimer's Center and Vanderbilt Institute for Clinical and Translational Research to offer a rich training environment for mentees. The training and research facilitated by this K24 mechanism renewal will not only advance knowledge regarding cardiovascular and cerebrovascular pathways contributing to the pathogenesis and clinical manifestation of Alzheimer's disease and small vessel disease, but it will also develop a cadre of next-generation cognitive aging researchers well- positioned to make meaningful contributions to the field.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$7,686 )
2025	2023	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Aging Research	000	11	4/25/2025	NON-COMPETING CONTINUATION	-$7,686
														Subtotal = -$7,686

Issue Date FY: 2023 ( Subtotal = $178,602 )
2023	2023	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Aging Research	000	11	1/18/2023	NON-COMPETING CONTINUATION	$178,602
														Subtotal = $178,602

Issue Date FY: 2022 ( Subtotal = $178,602 )
2022	2022	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Aging Research	000	10	12/17/2021	NON-COMPETING CONTINUATION	$178,602
														Subtotal = $178,602

Issue Date FY: 2021 ( Subtotal = $178,602 )
2021	2021	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Aging Research	000	9	1/29/2021	NON-COMPETING CONTINUATION	$178,602
														Subtotal = $178,602

Issue Date FY: 2020 ( Subtotal = $178,602 )
2020	2020	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Aging Research	000	8	1/22/2020	NON-COMPETING CONTINUATION	$178,602
														Subtotal = $178,602

Issue Date FY: 2019 ( Subtotal = $178,602 )
2019	2019	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Aging Research	003	7	7/16/2019	COMPETING CONTINUATION	$7,686
2019	2019	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Aging Research	001	7	12/20/2018	COMPETING CONTINUATION	$178,602
2019	2018	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Aging Research	002	6	7/16/2019	NON-COMPETING CONTINUATION	-$7,686
2019	2018	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Aging Research	000	6	12/18/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $178,602

Issue Date FY: 2018 ( Subtotal = $164,429 )
2018	2018	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Aging Research	000	6	11/30/2017	NON-COMPETING CONTINUATION	$164,429
2018	2018	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Aging Research	001	6	6/26/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $164,429

Issue Date FY: 2017 ( Subtotal = $164,429 )
2017	2017	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Aging Research	000	5	12/21/2016	NON-COMPETING CONTINUATION	$164,429
														Subtotal = $164,429

Issue Date FY: 2016 ( Subtotal = $164,429 )
2016	2016	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Aging Research	001	4	6/16/2016	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$92,565
2016	2016	VANDERBILT UNIVERSITY HOSPITAL, CHILDREN'S REHAB UNIT	1161 21ST AVENUE SOUTH	NASHVILLE	TN	37232	DAVIDSON	USA	Aging Research	000	3	12/10/2015	NON-COMPETING CONTINUATION	$164,429
2016	2016	VANDERBILT UNIVERSITY HOSPITAL, CHILDREN'S REHAB UNIT	1161 21ST AVENUE SOUTH	NASHVILLE	TN	37232	DAVIDSON	USA	Aging Research	002	3	6/16/2016	NON-COMPETING CONTINUATION	-$92,565
														Subtotal = $164,429

Issue Date FY: 2015 ( Subtotal = $164,429 )
2015	2015	VANDERBILT UNIVERSITY HOSPITAL, CHILDREN'S REHAB UNIT	1161 21ST AVENUE SOUTH	NASHVILLE	TN	37232	DAVIDSON	USA	Aging Research	001	2	2/11/2015	NON-COMPETING CONTINUATION	$16,444
2015	2015	VANDERBILT UNIVERSITY HOSPITAL, CHILDREN'S REHAB UNIT	1161 21ST AVENUE SOUTH	NASHVILLE	TN	37232	DAVIDSON	USA	Aging Research	000	2	11/20/2014	NON-COMPETING CONTINUATION	$147,985
														Subtotal = $164,429

Issue Date FY: 2014 ( Subtotal = $164,429 )
2014	2014	VANDERBILT UNIVERSITY HOSPITAL, CHILDREN'S REHAB UNIT	1161 21ST AVENUE SOUTH	NASHVILLE	TN	37232	DAVIDSON	USA	Aging Research	000	1	11/21/2013	NEW	$164,429
														Subtotal = $164,429

Grand Total All Awards = $1,707,469

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Risk factors and prevention targets for abnormal cognitive aging

Award Number: K24AG046373

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 01/01/2019

PERIOD OF PERFORMANCE END DATE: 12/31/2024

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