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Mentored Patient-Oriented Research on Adolescent Alcohol Misuse and Treatment

Award Number: K24AA026326
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 08/01/2018
PERIOD OF PERFORMANCE END DATE: 07/31/2028

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Mentored Patient-Oriented Research on Adolescent Alcohol Misuse and Treatment - PROJECT SUMMARY/ABSTRACT This K24 midcareer research and mentoring program aims to provide the candidate with protected time from direct patient care to conduct patient-oriented research (POR) on adolescent alcohol misuse and to mentor early-career clinical investigators in translational research in addiction science. To meet the challenge of advancing treatment options for the millions of American youth who struggle to reduce their alcohol use, the field requires highly trained researchers who can integrate cutting-edge concepts and methods from a variety of areas. As our understanding of addiction has become more complex, so too has the training needs of early- career scientists. For more than two decades, the candidate has built a productive and continuously funded POR program that translates theory-driven hypotheses from preclinical and human laboratory research to real world applications. The proposed integrated plan will facilitate the candidate’s ability to mentor early-career clinical investigators in POR and augment his capabilities as an independent clinician scientist. The research plan, which focuses on improving treatment options for adolescent alcohol misuse through digital health, dovetails the mentoring goals by providing a vehicle for mentoring early career scientists in: i) mechanisms of alcohol use disorder pathogenesis and treatment effects, ii) clinical trial methods, iii) ecological momentary assessment approaches, and iv) training in the responsible conduct of research. The candidate’s goal is to further develop and refine an experimental therapeutics approach that yields high quality information to inform decisions about whether further development of novel treatments is warranted. This K24 will support the collection of pilot data for an integrative digital health platform based on gold standard psychosocial interventions for treating AUD among adolescents. Adolescence is a critical period for the pathogenesis of AUD. Alcohol use typically begins during adolescence and prevalence rates for AUD peak before age 21. Yet, despite clinical demand, AUD treatments for youth rely on psychosocial interventions that yield only modest benefits. One potential way to improve adolescent alcohol treatment is to augment the best available psychosocial interventions with innovative digital health solutions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $186,398 )
2026	2026	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	000	9	7/14/2026	NON-COMPETING CONTINUATION	$186,398
														Subtotal = $186,398

Issue Date FY: 2025 ( Subtotal = $187,857 )
2025	2025	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	000	8	8/12/2025	NON-COMPETING CONTINUATION	$187,857
														Subtotal = $187,857

Issue Date FY: 2024 ( Subtotal = $189,259 )
2024	2024	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	002	7	7/18/2024	NON-COMPETING CONTINUATION	$189,259
2024	2023	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	001	6	6/27/2024	COMPETING CONTINUATION	$12,420
2024	2022	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	000	5	6/27/2024	NON-COMPETING CONTINUATION	-$12,420
														Subtotal = $189,259

Issue Date FY: 2023 ( Subtotal = $190,607 )
2023	2023	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	001	6	7/26/2023	COMPETING CONTINUATION	$190,607
2023	2022	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	000	5	7/25/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $190,607

Issue Date FY: 2022 ( Subtotal = $184,562 )
2022	2022	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	000	5	7/6/2022	NON-COMPETING CONTINUATION	$184,562
														Subtotal = $184,562

Issue Date FY: 2021 ( Subtotal = $185,644 )
2021	2021	BROWN UNIVERSITY IN PROVIDENCE IN THE STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	000	4	7/2/2021	NON-COMPETING CONTINUATION	$185,644
														Subtotal = $185,644

Issue Date FY: 2020 ( Subtotal = $185,712 )
2020	2020	BROWN UNIVERSITY IN PROVIDENCE IN THE STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	000	3	6/19/2020	NON-COMPETING CONTINUATION	$185,712
														Subtotal = $185,712

Issue Date FY: 2019 ( Subtotal = $187,389 )
2019	2019	BROWN UNIVERSITY IN PROVIDENCE IN THE STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	000	2	6/25/2019	NON-COMPETING CONTINUATION	$187,389
														Subtotal = $187,389

Issue Date FY: 2018 ( Subtotal = $188,123 )
2018	2018	BROWN UNIVERSITY IN PROVIDENCE IN THE STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	000	1	6/19/2018	NEW	$188,123
														Subtotal = $188,123

Grand Total All Awards = $1,685,551

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Mentored Patient-Oriented Research on Adolescent Alcohol Misuse and Treatment

Award Number: K24AA026326

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 08/01/2018

PERIOD OF PERFORMANCE END DATE: 07/31/2028

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