Monday, February 16, 2026 2/16/2026

Mentoring Multidisciplinary Patient-Oriented Research in Liver Disease

Award Number: K24AA022523
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 08/01/2013
PERIOD OF PERFORMANCE END DATE: 09/30/2025

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Mentoring Multidisciplinary Patient-Oriented Research in Liver Disease - Abstract Dr. Khalili is an established investigator and mentor as evidenced by her high-quality patient-oriented research, mentoring activities of young investigators, and her institutional leadership roles in research mentoring. Her long-term career objectives are: 1) to support and train early clinical investigators to transition to independent careers in multidisciplinary research, 2) to enhance effectiveness of research mentors to better meet the needs of their mentees, and 3) to lead efforts in better understanding of mechanisms of host and environmental interactions important to pathogenesis and progression of liver disease. During the next project period, she will use initial successes of the last project period to further expand her research and mentoring program, thereby increasing the pool of new investigators that successfully transition to independence. Dr. Khalili's multidisciplinary research program supported by continuous extramural funding will serve as the platform for providing mentorship for junior investigators from different disciplines. Moreover, she plans to lead national training efforts to enhance research mentor and mentee self-efficacy and mentee productivity especially among underrepresented groups in biomedical sciences. In the next project cycle she will capitalize on the rich academic environment of UCSF and its Clinical and Translational Sciences Institute resources to train mentees from different disciplines to enable them to compete successfully for mentored career development and independent awards in patient-oriented research. While the value of mentoring has been well-established, better understanding of which components of mentoring are most impactful on mentee success and implementing these strategies in training mentors are also critical to their young investigator career development. Dr. Khalili will use her leadership role in the UCSF Mentor Training Program to advance mentor training approaches through evaluation and program enhancement that build capacity of research mentors to effectively mentor young investigators and especially those from underrepresented backgrounds. Insulin resistance is an important contributor to negative impact of chronic liver diseases on human health and adipose tissue dysfunction has emerged as important to pathogenesis of liver disease. During the first project period, we gained insights into host, alcohol, and viral interactions influencing pathogenesis of abnormal glucose metabolism. The research plan for the next project period will extend these investigations to evaluate the influence of alcohol on adipose-tissue liver axis using chronic hepatitis C as a model of a common liver disease with high rates of adverse metabolic outcomes and in utilizing validated and direct measurements of insulin resistance in adipose tissue in at-risk populations. This research plan and resources from Dr. Khalili's ongoing research activities will provide mentoring and training opportunities for new and junior clinical investigators in patient-oriented multidisciplinary research in liver disease. The continuation of this award will allow Dr. Khalili to achieve these mentorship and research goals.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Alcohol Research Programs	000	10	2/10/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Alcohol Research Programs	000	10	5/13/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $193,511 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Alcohol Research Programs	000	10	5/3/2023	NON-COMPETING CONTINUATION	$193,511
														Subtotal = $193,511

Issue Date FY: 2022 ( Subtotal = $193,511 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Alcohol Research Programs	000	9	5/7/2022	NON-COMPETING CONTINUATION	$193,511
														Subtotal = $193,511

Issue Date FY: 2021 ( Subtotal = $193,511 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Alcohol Research Programs	000	8	5/3/2021	NON-COMPETING CONTINUATION	$193,511
														Subtotal = $193,511

Issue Date FY: 2020 ( Subtotal = $193,511 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Alcohol Research Programs	000	7	4/27/2020	NON-COMPETING CONTINUATION	$193,511
														Subtotal = $193,511

Issue Date FY: 2019 ( Subtotal = $193,511 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Alcohol Research Programs	001	6	4/19/2019	COMPETING CONTINUATION	$191,553
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Alcohol Research Programs	004	6	6/27/2019	COMPETING CONTINUATION	$20,899
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Alcohol Research Programs	002	6	5/22/2019	COMPETING CONTINUATION	$1,958
2019	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Alcohol Research Programs	000	5	4/19/2019	NON-COMPETING CONTINUATION	$0
2019	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Alcohol Research Programs	003	5	6/27/2019	NON-COMPETING CONTINUATION	-$20,899
														Subtotal = $193,511

Issue Date FY: 2017 ( Subtotal = $180,062 )
2017	2017	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Alcohol Research Programs	000	5	7/20/2017	NON-COMPETING CONTINUATION	$180,062
														Subtotal = $180,062

Issue Date FY: 2016 ( Subtotal = $180,062 )
2016	2016	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Alcohol Research Programs	000	4	7/22/2016	EXTENSION WITH OR WITHOUT FUNDS	$180,062
														Subtotal = $180,062

Issue Date FY: 2015 ( Subtotal = $180,062 )
2015	2015	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Alcohol Research Programs	000	3	7/15/2015	NON-COMPETING CONTINUATION	$180,062
														Subtotal = $180,062

Issue Date FY: 2014 ( Subtotal = $174,661 )
2014	2014	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Alcohol Research Programs	000	2	7/28/2014	NON-COMPETING CONTINUATION	$174,661
														Subtotal = $174,661

Issue Date FY: 2013 ( Subtotal = $180,062 )
2013	2013	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Alcohol Research Programs	000	1	7/30/2013	NEW	$180,062
														Subtotal = $180,062

Grand Total All Awards = $1,862,464

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Mentoring Multidisciplinary Patient-Oriented Research in Liver Disease

Award Number: K24AA022523

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 08/01/2013

PERIOD OF PERFORMANCE END DATE: 09/30/2025

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