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Effects of Transcranial Magnetic Stimulation on Social Cognition, Cognitive Processing, and Functional Brain Architecture in Psychopathy

Award Number: K23MH139637
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 09/12/2025
PERIOD OF PERFORMANCE END DATE: 08/31/2030

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Effects of Transcranial Magnetic Stimulation on Social Cognition, Cognitive Processing, and Functional Brain Architecture in Psychopathy - PROJECT SUMMARY/ABSTRACT This NIMH Career Development Award will support Dr. Drew Winters at the University of Colorado School of Medicine to conduct a trial focusing on transcranial magnetic stimulation (TMS) for intervention development in psychopathy. Dr. Winters will enroll adults ages 18-60 years (n=60) with psychopathy to test whether inhibitory TMS to the right dorsolateral prefrontal cortex (dlPFC) and excitatory TMS the right temporoparietal junction (TPJ) can improve social cognition (Aim 1), cognitive processing (Aim 2) and functional brain architecture (Aim 3). The career development plan supports the research aims and includes these training goals: 1) Develop expertise in TMS as a research tool; 2) Develop expertise in randomized controlled trial (RCT) design, implementation and analyses; 3) Develop expertise in analysis of brain data from TMS experiments to make causal inferences; 4) Develop expertise in psychopathic mechanisms. His mentors, Drs. Sakai, Mikulich, Oathes, and Waller are recognized experts in TMS, neuroimaging, statistics, clinical trials, advanced computational methods and causal inference with brain data, as well as psychopathy. The training plan and research protocol proposed under this career development award would provide the needed experiences, skill development and pilot data to help to launch Dr. Winters’ career as an independent scientist focusing on the neural mechanisms underlying social cognition, cognitive processing, and functional brain architecture implicated in psychopathy and antisocial phenotypes, along with novel treatment development.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $187,393 )
2026	2026	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Mental Health Research Grants	000	2	8/28/2026	NON-COMPETING CONTINUATION	$187,393
														Subtotal = $187,393

Issue Date FY: 2025 ( Subtotal = $188,976 )
2025	2025	THE REGENTS OF THE UNIV. OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Mental Health Research Grants	001	1	9/17/2025	NEW	$0
2025	2025	THE REGENTS OF THE UNIV. OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Mental Health Research Grants	000	1	9/12/2025	NEW	$188,976
														Subtotal = $188,976

Grand Total All Awards = $376,369

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Effects of Transcranial Magnetic Stimulation on Social Cognition, Cognitive Processing, and Functional Brain Architecture in Psychopathy

Award Number: K23MH139637

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 09/12/2025

PERIOD OF PERFORMANCE END DATE: 08/31/2030

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