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Advancing Computational Linguistic Biomarkers of Disorganized Speech in Psychosis

Award Number: K23MH130750
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 09/01/2022
PERIOD OF PERFORMANCE END DATE: 09/02/2025

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Advancing Computational Linguistic Biomarkers of Disorganized Speech in Psychosis - Project Summary Disorganization in psychosis has important clinical implications but is under-studied. Several lines of evidence suggest that disorganization reflects higher genetic loading and worse outcomes, and is sensitive to treatment response and relapse. We will use computational linguistics to measure disorganization in a sensitive, objective, efficient, reproducible, and repeatable way. Speech will be elicited with open-ended and structured tasks from 270 people with schizophrenia spectrum disorders and mood disorders with psychotic features, generating ~30,000 sentences across the sample. Findings will be validated in an existing independent dataset. We will measure psychosis symptoms, functioning, and cognition in both samples. Incoherence and inefficiency will be labeled for individual sentences and rated for the overall participant. Our Specific Aims are as follows: (1) Develop deep-learning methods to classify sentence-level disorganization; (2) Integrate across computational features to predict participant-level disorganization; (3) Predict key participant characteristics using linguistic features. An integrated training plan will combine hands-on experience through these research aims with mentorship, coursework, self-study, seminars, and conferences to achieve the following Training Goals: (1) Proficiency in computational linguistics and machine learning methods, (2) Expertise in validating clinically-relevant biomarkers, and (3) Development as a physician-scientist. This work provides the foundation needed to develop cutting-edge computational methods into biomarkers of disorganization and key psychosis outcomes. We lay the groundwork for future studies that leverage these features as early markers of treatment response and relapse, and that use these features to connect behavioral phenotypes with underlying biology. The proposed project builds on my existing expertise to develop the technical proficiency and expertise in psychosis biomarker research I need to lead new discoveries in this area as an independent physician- investigator.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH	350 COMMUNITY DR	MANHASSET	NY	11030	NASSAU	USA	Mental Health Research Grants	000	4	12/22/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2025	THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH	350 COMMUNITY DR	MANHASSET	NY	11030	NASSAU	USA	Mental Health Research Grants	000	4	7/24/2025	NON-COMPETING CONTINUATION	$195,480
2025	2025	THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH	350 COMMUNITY DR	MANHASSET	NY	11030	NASSAU	USA	Mental Health Research Grants	001	4	8/20/2025	NON-COMPETING CONTINUATION	-$195,480
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $195,480 )
2024	2024	THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH	350 COMMUNITY DR	MANHASSET	NY	11030	NASSAU	USA	Mental Health Research Grants	000	3	7/26/2024	NON-COMPETING CONTINUATION	$195,480
														Subtotal = $195,480

Issue Date FY: 2023 ( Subtotal = $195,480 )
2023	2023	FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH, THE	350 COMMUNITY DR	MANHASSET	NY	11030	NASSAU	USA	Mental Health Research Grants	001	2	8/22/2023	NON-COMPETING CONTINUATION	$195,480
2023	2022	FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH, THE	350 COMMUNITY DR	MANHASSET	NY	11030	NASSAU	USA	Mental Health Research Grants	000	1	8/21/2023	NEW	$0
														Subtotal = $195,480

Issue Date FY: 2022 ( Subtotal = $195,480 )
2022	2022	FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH, THE	350 COMMUNITY DR	MANHASSET	NY	11030	NASSAU	USA	Mental Health Research Grants	000	1	8/18/2022	NEW	$195,480
														Subtotal = $195,480

Grand Total All Awards = $586,440

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Advancing Computational Linguistic Biomarkers of Disorganized Speech in Psychosis

Award Number: K23MH130750

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 09/01/2022

PERIOD OF PERFORMANCE END DATE: 09/02/2025

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