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A Precision Medicine Approach to Target Engagement for Emotion Regulation

Award Number: K23MH126211
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 01/01/2022
PERIOD OF PERFORMANCE END DATE: 12/31/2025

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A Precision Medicine Approach to Target Engagement for Emotion Regulation - Emotion dysregulation is a transdiagnostic maintenance factor involved in a wide array of costly and debilitating psychiatric disorders. Although numerous full-model behavioral health treatments have been designed to improve patients’ emotion regulation capacities, these treatments consist of multiple components, making it difficult to discern which are active mechanisms leading to reductions in negative emotion intensity. Further, it is unclear whether the delivery of these evidence-based components can be tailored to the individual patient. The proposed Mentored Patient-Oriented Research Career Development Award (K23) is a four-year plan to support the applicant’s long-term career goal of becoming a clinical scientist with expertise in (1) identifying active mechanisms of emotion regulation interventions for psychopathology, (2) tailoring these interventions to individual patients, and (3) developing scalable interventions for wide dissemination. The applicant’s training and career thus far are aligned with these long-term goals. Throughout his graduate work, he conducted studies testing emotion regulation mechanisms in transdiagnostic samples and used this information to explore for whom these mechanisms were most impactful. The immediate goals of the K23 award are for the applicant to become skilled at intensive longitudinal experimental designs to disaggregate between- from within-person mechanisms of change and enhance his proficiency in conducting and analyzing multimethod assessments of emotion regulation. This proposal uses a two-phase approach to address these goals. In line with an experimental therapeutics approach, the goal of Phase 1 is to compare the effects of teaching one or three emotion regulation skills on daily changes in negative emotion intensity among participants with elevated emotion dysregulation. The first goal of Phase 2 is to apply a personalization algorithm based on Phase 1 data to an independent sample to determine which baseline participant characteristics predict greater reductions in negative emotion intensity in each experimental condition. The second goal of Phase 2 is to compare the effects of teaching participants emotion regulation skill(s) according to their optimal or non-optimal delivery condition, based on the personalization algorithm. The training plan closely matches the proposed research and long-term goals, including (a) developing advanced understanding in statistical methods to test between- and within-person mechanisms of emotion regulation interventions, (b) gaining proficiency in applying novel personalization algorithms, and (c) enhancing expertise in the implementation and analysis of multimethod assessments of emotion regulation skills. The broader aim of this research and training is to address the need for more efficient, personalized, and scalable interventions for transdiagnostic psychiatric conditions, in line with the NIMH strategic plan. This study will answer important theoretical and practical questions about the efficacy of different emotion regulation mechanisms on clinical outcomes that may promote the development of more targeted and disseminable interventions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $110,027 )
2025	2025	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE	LEXINGTON	KY	40526	FAYETTE	USA	Mental Health Research Grants	000	4	1/27/2025	NON-COMPETING CONTINUATION	$110,027
														Subtotal = $110,027

Issue Date FY: 2024 ( Subtotal = $144,789 )
2024	2024	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE	LEXINGTON	KY	40526	FAYETTE	USA	Mental Health Research Grants	000	3	1/19/2024	NON-COMPETING CONTINUATION	$165,745
2024	2024	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE	LEXINGTON	KY	40526	FAYETTE	USA	Mental Health Research Grants	001	3	7/12/2024	NON-COMPETING CONTINUATION	-$20,956
														Subtotal = $144,789

Issue Date FY: 2023 ( Subtotal = $168,506 )
2023	2023	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	Mental Health Research Grants	000	2	1/26/2023	NON-COMPETING CONTINUATION	$168,506
														Subtotal = $168,506

Issue Date FY: 2022 ( Subtotal = $168,592 )
2022	2022	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	Mental Health Research Grants	000	1	12/23/2021	NEW	$168,592
2022	2022	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	Mental Health Research Grants	001	1	12/28/2021	NEW	$0
														Subtotal = $168,592

Grand Total All Awards = $591,914

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A Precision Medicine Approach to Target Engagement for Emotion Regulation

Award Number: K23MH126211

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 01/01/2022

PERIOD OF PERFORMANCE END DATE: 12/31/2025

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