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Neuroanatomical substrates of cognition in mosaic Turner syndrome

Award Number: K23MH097120
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 03/01/2012
PERIOD OF PERFORMANCE END DATE: 12/31/2015

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Neuroanatomical substrates of cognition in mosaic Turner syndrome - DESCRIPTION (provided by applicant): The purpose of this K23 Mentored Patient-Oriented Research Career Development Award application is to support my short-term career objective of integrating multimodal neuroimaging and genetic techniques in the study of cognitive and behavioral differences in young girls with Turner syndrome (TS). TS is characterized by the complete or partial loss of an X chromosome. The neurocognitive phenotype may be characterized by deficits in visuospatial, executive function and social cognition domains. These impairments have a significant impact on adaptive functioning in affected individuals. Previous neuroimaging studies in TS have largely limited investigation to individuals with complete X-monosomy. Therefore, the research proposed here will be one of the first to identify structural and white matter brain differences in young girls with the mosaic karyotype of TS (moTS). Specifically, neuropsychological assessments, structural magnetic resonance imaging and diffusion imaging methods, will be used to investigate neuroanatomical substrates in young girls with moTS. Our hypotheses predict that volumetric and white matter differences will be observed in regions correlated to: (1) visuospatial skills - including parietal and occipital corties and frontal-parietal pathways, (2) executive function - including frontal cortex and prefrontal-striatal-parietal pathways, and (3) social cognition - including amygdala, orbitofrontal, fusiform and superior temporal regions and related pathways. Furthermore, we will investigate a putative 'dosage' effect of X chromosome genes on brain structure and behavior, by elucidating the effect of mosaicism on severity of neurocognitive phenotype in individuals with moTS. Understanding the influence of mosaicism in TS relative to typical development will allow enhanced understanding of the role of the X chromosome in cognitive-behavioral development and inform future development of preventative and treatment strategies for this disorder. My previous clinical work with children with developmental disorders, and neuroimaging experience in individuals with monosomic karyotype of TS, have laid a solid foundation for helping me achieve these aims. However, I propose to gain further expertise in incorporating sophisticated neuroimaging methods, genomics and statistics to enhance these skills. The proposed integrated research, mentorship and didactic training programs, combined with the outstanding research environment at Stanford University will foster my long-term career objective to be an independent investigator studying gene, brain and behavior interactions in childhood neurodevelopmental syndromes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2015 ( Subtotal = $181,410 )
2015	2015	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Mental Health Research Grants	000	4	12/13/2014	NON-COMPETING CONTINUATION	$181,410
														Subtotal = $181,410

Issue Date FY: 2014 ( Subtotal = $181,343 )
2014	2014	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Mental Health Research Career/Scientist Development Awards	000	3	12/17/2013	NON-COMPETING CONTINUATION	$181,343
														Subtotal = $181,343

Issue Date FY: 2013 ( Subtotal = $181,399 )
2013	2013	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Mental Health Research Career/Scientist Development Awards	000	2	12/28/2012	NON-COMPETING CONTINUATION	$181,399
														Subtotal = $181,399

Issue Date FY: 2012 ( Subtotal = $180,827 )
2012	2012	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Mental Health Research Career/Scientist Development Awards	000	1	2/24/2012	NEW	$180,827
														Subtotal = $180,827

Grand Total All Awards = $724,979

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Neuroanatomical substrates of cognition in mosaic Turner syndrome

Award Number: K23MH097120

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 03/01/2012

PERIOD OF PERFORMANCE END DATE: 12/31/2015

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