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Eosinophilic Mucin Chronic Rhinosinusitis: Determining the multi-level factors that mediate disease and disparities

Award Number: K23MD018458
ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

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PROJECT SUMMARY/ ABSTRACT Goal: This proposal provides a structured research training program under the guidance of mentors and advisors in related fields to promote Dr. Levine’s development into an independent clinician-scientist. Her long-term goal is leading a multidisciplinary research teams to develop patient-centered treatment pathways and interventions that improve outcomes and mitigate disparities in eosinophilic mucin chronic rhinosinusitis. Research: Chronic rhinosinusitis is a debilitating disease of the paranasal sinuses that affects up to 16% of the United States (US) population, causing intractable congestion, smell loss, and persistent headaches that can lead to permeant and life-threatening morbidities. Research in diverse populations demonstrates that Hispanic and Black patients are more likely to have severe chronic rhinosinusitis disease subtypes such as eosinophilic mucin chronic rhinosinusitis (EMRS), a subtype common in the southern US. Hispanic and Black EMRS patients present with more advanced disease, have worse post-treatment outcomes, and have high rates of morbidity including facial bone deformities and vision changes. The etiology behind the disparities in EMRS presentation and outcomes are unknown. Fundamental questions about how to reduce disease burden cannot be answered until we understand the factors that influence EMRS treatment outcomes. The goal of this proposal is generating evidence to predict EMRS treatment outcomes and reduce health disparities. We will employ a prospective longitudinal cohort study and use semi-structured interviews of patients and providers to identify important EMRS treatment outcome determining factors. The central hypothesis of this proposal is that EMRS disparities result from the interplay of individual- and community-level health determinants and environmental exposures that have quantifiable impacts on EMRS clinical and biological outcome measures. To test this, we will: 1) develop a computation model integrating multi-level factors to predict EMRS post-surgical outcomes; 2) determine best- practices to facilitate efficient and effective clinician-patient communication and EMRS care; 3) develop a pilot intervention to reduce delays in care. We will engage stakeholders in pilot intervention development and feedback. The proposed research aligns with the NIMHD mission to develop new research methods to improve minority health and reduce health disparities. The research results will help inform clinical practice and treatment recommendations to improve the quality of EMRS care and reduce disparities. Training: To accomplish these aims Dr. Levine will receive mentorship, focused didactics, one-on-one tutorials, and hands-on training in team science and mixed methods research, incorporating important aspects of computational modeling and qualitative research. She will establish a robust rhinology research network to facilitate a pathway to independence. A NIMHD K23 award will provide Dr. Levine with the protected time and essential training to achieve her career goals of improving outcomes and reducing disparities for EMRS patients.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $154,440 )
2024	2024	UNIVERSITY OF MIAMI	1320 S DIXIE HWY STE 1200	CORAL GABLES	FL	33146	MIAMI-DADE	USA	Minority Health and Health Disparities Research	002	2	6/17/2024	NON-COMPETING CONTINUATION	$15,444
2024	2024	UNIVERSITY OF MIAMI	1320 S DIXIE HWY STE 1200	CORAL GABLES	FL	33146	MIAMI-DADE	USA	Minority Health and Health Disparities Research	001	2	1/24/2024	NON-COMPETING CONTINUATION	$138,996
2024	2023	UNIVERSITY OF MIAMI	1400 NW 10TH AVE	MIAMI	FL	33136	MIAMI-DADE	USA	Minority Health and Health Disparities Research	000	1	10/11/2023	NEW	$0
														Subtotal = $154,440

Issue Date FY: 2023 ( Subtotal = $154,440 )
2023	2023	UNIVERSITY OF MIAMI	1400 NW 10TH AVE	MIAMI	FL	33136	MIAMI-DADE	USA	Minority Health and Health Disparities Research	000	1	7/7/2023	NEW	$154,440
														Subtotal = $154,440

Grand Total All Awards = $308,880

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Eosinophilic Mucin Chronic Rhinosinusitis: Determining the multi-level factors that mediate disease and disparities

Award Number: K23MD018458

ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

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