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Characterizing Hypertension After Pregnancy Through patient-centered Research (CHAPTeR)

Award Number: K23HL185920
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 08/15/2026
PERIOD OF PERFORMANCE END DATE: 07/31/2031

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Characterizing Hypertension After Pregnancy Through patient-centered Research (CHAPTeR) - PROJECT SUMMARY/ABSTRACT Cardiovascular disease (CVD) affects over 60 million American women. Women’s CVD has strong origins in biopsychosocial cascades that are activated in pregnancy and amplified postpartum. De novo postpartum hypertension affects over 18% of women in the first postpartum year and is a clinical manifestation of these cascades, increasing a woman’s lifetime risk of cardiovascular mortality by 3-fold. As such, postpartum hypertension serves as a critical, actionable target for lifetime CVD risk modification. Although detection and management of postpartum hypertension are well-established interventions capable of mitigating CVD risk, only half of women receive the requisite evidence-based postpartum services because scalable, patient- centered primary care models that respond to the priorities of postpartum individuals remain scarce. Furthermore, limited understanding of the biopsychosocial cascades that provoke postpartum hypertension has hindered creation of innovative interventions for those with the highest burden of CVD risk. The proposed project, Characterizing Hypertension After Pregnancy Through patient-centered Research (CHAPTeR), seeks to fill foundational knowledge gaps critical to developing patient-centered strategies to address postpartum hypertension and related CVD risk factors via the following Specific Aims: 1) Identify biopsychosocial profiles of peripartum risk that are associated with subsequent de novo hypertension during the postpartum year; 2) Elucidate patient experiences and preferences regarding postpartum cardiovascular health promotion; and 3) Develop and pilot a self-management support intervention to improve CVD risk awareness and cardiovascular health promotion among postpartum individuals. Dr. Gordon will utilize innovative methodologies such as machine learning and journey mapping to critically shape future programs of research on the pathogenesis of CVD risk factors and create an intervention map to inform development of postpartum cardiovascular health interventions, in alignment with NHLBI research priorities. Additionally, her pilot trial will utilize patient engagement in a pragmatic trial setting to build interventions capable of preventing postpartum CVD that are informed by lived experience. Dr. Gordon will enhance her skills in patient engagement and statistical analysis, as well as receive advanced training in machine learning, patient preference elicitation, and clinical trial design. She will be mentored by a team of multidisciplinary federally funded investigators with expertise in patient- centered outcomes and pragmatic trial design (Dr. Brill), biostatistics (Dr. Fernandez), and peripartum CVD epidemiology (Dr. Venkatesh). The career development and evidence generated by CHAPTeR will enable Dr. Gordon’s transition to an independent investigator in patient-engaged research in postpartum mitigation of CVD risk. Her work in CHAPTeR will pave the way towards developing a predictive model of postpartum hypertension as well as designing larger trials of postpartum CVD risk prevention interventions that will target risk factors and patient preferences for postpartum hypertension care.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $170,964 )
2026	2026	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Cardiovascular Diseases Research	000	1	8/14/2026	NEW	$170,964
														Subtotal = $170,964

Grand Total All Awards = $170,964

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Characterizing Hypertension After Pregnancy Through patient-centered Research (CHAPTeR)

Award Number: K23HL185920

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 08/15/2026

PERIOD OF PERFORMANCE END DATE: 07/31/2031

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