Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

ECLIPSE- Extent and CLinical Impact of Pigment in Pulse oximeter Saturation Error in ICU infants

Award Number: K23HL181400
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 06/01/2026
PERIOD OF PERFORMANCE END DATE: 05/31/2031

Group Awards By:

View Award Description

ECLIPSE- Extent and CLinical Impact of Pigment in Pulse oximeter Saturation Error in ICU infants - PROJECT SUMMARY/ABSTRACT Preterm infants often have underdeveloped lungs, and their immature organs are sensitive to under- or over-delivery of oxygen. Landmark studies in preterm infants have established the association of hypoxemia (oxygen saturation <90%) with mortality and adverse pulmonary and neurodevelopmental outcomes. Pulse oximeters estimate blood oxygen saturation by emitting light through the skin and measuring the changes in light absorption by oxygenated and deoxygenated hemoglobin. Pulse oximeters are used universally in neonatal intensive care units to guide the respiratory care of neonates. However, recent studies in adults report that pulse oximeters can overestimate blood oxygen saturation in patients with dark-pigmented skin. Such pulse-oximeter inaccuracy (POI) is defined as the difference between peripheral oxygen saturation, measured with a pulse oximeter (SpO2), and arterial oxygen saturation, measured with an arterial blood gas test (SaO2). In patients with dark-pigmented skin, POI is significant because it results in occult or 'missed’ hypoxemia. While delayed recognition of hypoxemia and its associated adverse consequences have been demonstrated in adults with dark-pigmented skin, we do not know whether POI occurs in neonates. Because preterm neonates often spend months in the ICU receiving respiratory support, the adverse effects of POI could be significant, particularly for patients with dark-pigmented skin. Objective continuous measurements of skin pigment are lacking but necessary to quantify POI resulting from skin pigmentation and inform new algorithms to improve the accuracy of pulse oximeters. My research Aims are to (1) evaluate the extent of POI across infants with various levels of skin pigmentation through cross-sectional and repeated measurements and (2) determine the burden of early occult hypoxemia in dark- versus light-pigmented preterm infants and its association with subsequent pulmonary outcomes. My novel approach combines spectroscopy to quantify skin pigment and prospective collection of clinically relevant physiological and clinical data to precisely quantify POI, the real- world burden of occult hypoxemia, and respiratory outcomes in a robust cohort of critically ill neonates. The University of Arkansas for Medical Sciences and Arkansas Children’s hospitals provide an ideal environment for the proposed work and career development. This K23 will enable Dr. Sharma to develop the expertise in curating a large, multi-sourced dataset by leading a multisite team of clinical informaticists, data engineers, and biostatisticians. The career development plan will advance Dr. Sharma’s ability to analyze and interpret the impact of POI on clinical outcomes and disseminate findings to the scientific community and participants, as well as build competence in medical device development and regulatory science. Dr. Sharma will be supported by an interdisciplinary team of mentors and advisors with expertise in prospective clinical studies in preterm infants, clinical informatics, advanced biostatistical methods, medical device development, biomedical engineering, and health outcomes research to facilitate her transition to an independent clinician scientist.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $184,882 )
2026	2026	ARKANSAS CHILDREN'S RESEARCH INSTITUTE	13 CHILDREN'S WAY	LITTLE ROCK	AR	72202	PULASKI	USA	Lung Diseases Research	000	1	5/26/2026	NEW	$184,882
														Subtotal = $184,882

Grand Total All Awards = $184,882

Top

All Categories

About

Search

Reports

Data Submission

Award Information

ECLIPSE- Extent and CLinical Impact of Pigment in Pulse oximeter Saturation Error in ICU infants

Award Number: K23HL181400

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 06/01/2026

PERIOD OF PERFORMANCE END DATE: 05/31/2031

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer