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Postpartum low-dose aspirin to augment vascular recovery following a hypertensive disorder of pregnancy

Award Number: K23HL168356
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 08/01/2024
PERIOD OF PERFORMANCE END DATE: 07/31/2027

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Postpartum low-dose aspirin to augment vascular recovery following a hypertensive disorder of pregnancy - PROJECT ABSTRACT Cardiovascular disease (CVD) is the leading cause of death in women worldwide and despite declines in all other age groups, mortality rates attributed to CVD are increasing in women of childbearing age. Preeclampsia is a well-established risk factor for CVD across diverse patient populations, however, there are currently no evidence-based interventions targeting this at-risk patient population. While blood pressure control is the cornerstone of postpartum management, emerging evidence suggests that management of hypertension alone does not fully mitigate CVD risk after preeclampsia. The overall goal of this line of research is to begin to develop and test novel pharmacologic interventions for postpartum management following preeclampsia, representing a paradigm shift focused on endothelial recovery postpartum in addition to blood pressure control. In this application, the objective is to conduct a single-site pilot trial to assess the feasibility and effect of low- dose aspirin to augment vascular recovery in the immediate postpartum period after preeclampsia through two specific aims: to pilot test the feasibility of conducting a randomized controlled trial of postpartum low-dose aspirin vs. placebo, and 2) to assess the effect of postpartum aspirin on endothelial function and blood pressure. Our central hypothesis is that postpartum administration of low-dose aspirin following preeclampsia will be feasible, improve endothelial function, and lower BP at 6 months postpartum. The research proposed in this application is innovative in its novel adaptation of an evidence-based strategy to improve vascular function and postpartum blood pressure in an understudied population with significant morbidity during a critical time period. This proposal is significant as it will provide an opportunity to assess the feasibility and explore the effect of low-dose aspirin on vascular function in addition to blood pressure. Effective interventions to improve postpartum hypertension care and reduce long-term cardiovascular risk have broad implications for improving maternal morbidity and reducing disparities in care. Our findings will provide a valuable framework to inform a subsequent large-scale randomized trial of low-dose aspirin in the postpartum period following preeclampsia. Successful completion of this line of research would represent a transformation in postpartum management of women with hypertensive disorders of pregnancy and have a direct impact to improve hypertension and cardiovascular-related maternal morbidity and mortality.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $172,223 )
2025	2025	WOMEN & INFANTS HOSPITAL OF RHODE ISLAND	101 DUDLEY ST	PROVIDENCE	RI	02905	PROVIDENCE	USA	Cardiovascular Diseases Research	002	3	8/12/2025	NON-COMPETING CONTINUATION	$172,223
2025	2024	WOMEN & INFANTS HOSPITAL OF RHODE ISLAND	101 DUDLEY ST	PROVIDENCE	RI	02905	PROVIDENCE	USA	Cardiovascular Diseases Research	000	2	10/19/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2025	2023	MAGEE-WOMENS RESEARCH INSTITUTE AND FOUNDATION	3240 CRAFT PL STE 100	PITTSBURGH	PA	15213	ALLEGHENY	USA	Cardiovascular Diseases Research	001	1	4/1/2025	NEW	$0
														Subtotal = $172,223

Issue Date FY: 2024 ( Subtotal = $167,722 )
2024	2024	WOMEN & INFANTS HOSPITAL OF RHODE ISLAND	101 DUDLEY ST	PROVIDENCE	RI	02905	PROVIDENCE	USA	Cardiovascular Diseases Research	001	2	9/17/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$167,722
2024	2023	MAGEE-WOMENS RESEARCH INSTITUTE AND FOUNDATION	3240 CRAFT PL STE 100	PITTSBURGH	PA	15213	ALLEGHENY	USA	Cardiovascular Diseases Research	000	1	9/16/2024	NEW	$0
														Subtotal = $167,722

Issue Date FY: 2023 ( Subtotal = $167,376 )
2023	2023	MAGEE-WOMENS RESEARCH INSTITUTE AND FOUNDATION	3339 WARD ST	PITTSBURGH	PA	15213	ALLEGHENY	USA	Cardiovascular Diseases Research	000	1	8/7/2023	NEW	$167,376
														Subtotal = $167,376

Grand Total All Awards = $507,321

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Postpartum low-dose aspirin to augment vascular recovery following a hypertensive disorder of pregnancy

Award Number: K23HL168356

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 08/01/2024

PERIOD OF PERFORMANCE END DATE: 07/31/2027

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