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Improving Care After Cardiac Arrest by Informing Surrogate Decision Makers - Extension

Award Number: K23HL138164
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 08/18/2017
PERIOD OF PERFORMANCE END DATE: 03/09/2022

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Improving Care After Cardiac Arrest by Informing Surrogate Decision Makers - Extension - PROJECT SUMMARY – Improving care after cardiac arrest by informing surrogate decision makers Survival and neurological recovery after cardiac arrest are highly variable, driven in part by inconsistent hospital care following successful resuscitation. Significant variability in delivery of evidence based, guideline concordant care has been associated with differences in overall outcome from cardiac arrest. When guidelines are followed, survival with good neurologic recovery is improved. However, adherence to guidelines regarding delayed decision to withdraw life support has been highly variable across US hospitals. Reasons attributed to early withdrawal of life sustaining therapy include poor knowledge of national and international guidelines, requests from family for early outcome predications, and incomplete family comprehension of critical care. In order to encourage utilization of guideline concordant delayed neuro-prognostication and concomitant withdrawal of life-sustaining therapy (>72 hours after resuscitation) we propose a novel approach; to educate and inform surrogate decision makers on neuro-prognostic uncertainty and guideline concordant care. The research proposed in this career development award COVID extension will pilot test a novel intervention that will encourage improved guideline adherence on neuro-prognostication and delayed WLST as well as to support the continued development of Dr. Sarah Perman, an early investigator committed to improving outcomes from out-of-hospital cardiac arrest. In this extension, we will continue a pilot trial of the Tool to EMPOwer (TEMPO) Surrogate Decision Makers of comatose survivors of cardiac arrest at the University of Colorado Hospital. This pilot is intended to determine feasibility and acceptability of the tool as well as knowledge transferred regarding post-cardiac arrest care. We intend to utilize the pilot trial to prepare for widespread implementation of TEMPO. The results of the pilot trial will further inform the design of a multi- center pragmatic clinical trial to implement the educational tool in order to encourage guideline concordant post-cardiac arrest care including delayed neuro-prognostication and delayed withdrawal of life-sustaining therapy. Overall, we hypothesize that informing surrogate decision makers on guideline concordant care, will result in delayed decisions to withdraw life-sustaining therapy and allow the post-arrest patient adequate timing for appropriate neuro-prognostication and awakening, thus improving outcomes from out-of-hospital cardiac arrest. This will be the subject of a future independent research proposal by the applicant.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$3,127 )
2023	2021	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Cardiovascular Diseases Research	000	4	12/6/2022	SUPPLEMENT FOR EXPANSION	-$3,127
														Subtotal = -$3,127

Issue Date FY: 2021 ( Subtotal = $67,408 )
2021	2021	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Cardiovascular Diseases Research	000	4	9/9/2021	SUPPLEMENT FOR EXPANSION	$67,408
														Subtotal = $67,408

Issue Date FY: 2020 ( Subtotal = $224,199 )
2020	2020	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Cardiovascular Diseases Research	000	4	7/3/2020	NON-COMPETING CONTINUATION	$170,640
2020	2020	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	NIH Office of Research on Women's Health	001	4	8/7/2020	SUPPLEMENT FOR EXPANSION	$53,559
														Subtotal = $224,199

Issue Date FY: 2019 ( Subtotal = $170,640 )
2019	2019	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Cardiovascular Diseases Research	000	3	5/24/2019	NON-COMPETING CONTINUATION	$170,640
														Subtotal = $170,640

Issue Date FY: 2018 ( Subtotal = $170,640 )
2018	2018	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Cardiovascular Diseases Research	000	2	6/6/2018	NON-COMPETING CONTINUATION	$170,640
														Subtotal = $170,640

Issue Date FY: 2017 ( Subtotal = $170,640 )
2017	2017	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Cardiovascular Diseases Research	000	1	8/18/2017	NEW	$170,640
														Subtotal = $170,640

Grand Total All Awards = $800,400

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Improving Care After Cardiac Arrest by Informing Surrogate Decision Makers - Extension

Award Number: K23HL138164

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 08/18/2017

PERIOD OF PERFORMANCE END DATE: 03/09/2022

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